Effects of Spermidine on Mouse Gut Morphology, Metabolites, and Microbial Diversity

Spermidine is a class of biologically active organic small molecules that play an important role in maintaining intestinal homeostasis. The specific objective of this study was to explore the effects of spermidine on intestinal morphology, metabolites, and microbial diversity in mice. We showed that...

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Bibliographic Details
Published in:Nutrients 2023-02, Vol.15 (3), p.744
Main Authors: Jiang, Dong-Mei, Wang, Ze-Long, Yang, Jia-Di, Wang, Xin, Niu, Chun-Yang, Ji, Cheng-Weng, Ling, Wei-Kang, An, Xiao-Guang, Guo, Yong-Ni, Sun, Qian, Bai, Lin, Li, De-Bing, Si, Xiao-Hui, Kang, Bo
Format: Article
Language:English
Subjects:
Animals
Bacteria
Biological activity
Body weight
Chromatography
Colon
Drinking water
Gastrointestinal Microbiome - physiology
Gastrointestinal system
Health aspects
Homeostasis
Ileum
Intestinal microflora
Intestinal Mucosa - metabolism
Intestine
Jejunum
Lactic acid
Lactic acid bacteria
Mass spectrometry
Metabolism
Metabolites
Microbiota (Symbiotic organisms)
Microorganisms
Morphology
Physiological aspects
Polyamines
rRNA 16S
Scientific imaging
Signal transduction
Software
Spermidine
Spermidine - pharmacology
Statistical analysis
Succinic acid
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Summary:Spermidine is a class of biologically active organic small molecules that play an important role in maintaining intestinal homeostasis. The specific objective of this study was to explore the effects of spermidine on intestinal morphology, metabolites, and microbial diversity in mice. We showed that 0.3 mmol/L of spermidine significantly promoted the growth of ileal villi ( < 0.05), and 3.0 mmol/L of spermidine significantly increased the body weight of mice and promoted the growth of jejunum villi ( < 0.05). The 16S rDNA sequencing results indicated that 3.0 mmol/L of spermidine affected the balance of the intestinal flora by increasing the abundance of intestinal Lactic acid bacteria and reducing the abundance of harmful bacteria ( and ). Additionally, spermidine affects the levels of microbial metabolites such as succinic acid and . In summary, spermidine affects intestinal morphology and regulates intestinal flora and metabolites, and this study has provided a new understanding of spermidine's effects on the intestinal tract.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15030744