HELLP syndrome and COVID-19: A minor revision of a possible new “COVID-19-linked HELLP-like syndrome”

• Published in: European journal of obstetrics & gynecology and reproductive biology 2023-04, Vol.283, p.90-94
• Main Authors: da Cunha Sobieray, Narcizo Leopoldo Eduardo, Zanela, Mariluci, Padilha, Sérgio Lunardon, Klas, Cynthia Fontoura, de Carvalho, Newton Sérgio
• Format: Article
• Language: English
• Subjects: COVID-19; COVID-19 - diagnosis; COVID-19-linked HELLP-like syndrome; Diagnosis, Differential; Eclampsia; Female; HELLP syndrome; HELLP Syndrome - diagnosis; Humans; Pre-Eclampsia - diagnosis; Preeclampsia; Pregnancy; Review
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/j.ejogrb.2023.02.005

To report the characteristics described in the literature on a possible new “COVID-19-linked HELLP-like syndrome” in pregnant women with COVID-19: its association with the severity; prevalence; clinical; laboratory; pathophysiological and therapeutic management differences from the classic HELLP syndrome and their impact on outcomes. Observational, cohort, case-control, case-series and case-report studies were included. Data were extracted independently by the authors of the study, to ensure accuracy, consistency and performed the quality assessment. The database search resulted in 77 references, of which two satisfied the eligibility criteria. In these 2 studies we found a possible “COVID-19-linked HELLP-like syndrome”, associated with severe COVID-19. There is a high possibility of the existence of “COVID-19-linked HELLP-like syndrome” and its association with severe COVID-19 in pregnant women, with a prevalence of 28,6%. Some characteristics of “COVID-19-linked HELLP-like syndrome” and the classic HELLP syndrome are similar. Differential diagnosis indicated two different types of therapeutic management: conservative for “COVID-19-linked HELLP-like syndrome” and delivery for the HELLP syndrome. HELLP clinical management is mandatory for both.