Influence of Baseline Diastolic Blood Pressure on the Effects of Systolic Blood Pressure Lowering on Cognitive Function in Type 2 Diabetes Mellitus

Lowering of systolic blood pressure (SBP) in patients with low diastolic blood pressure (DBP), can further lower DBP. This can potentially decrease cerebral perfusion and cognition. We examined the influence of baseline DBP on the effect of lowering SBP on cognition. This is a post hoc analysis of t...

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Bibliographic Details
Published in:American journal of hypertension 2023-02, Vol.36 (2), p.120-125
Main Authors: Gupta, Aditi, Boucher, Robert, Wei, Guo, Gronseth, Gary, Parks, Adam, Beddhu, Srinivasan
Format: Article
Language:English
Subjects:
Aged
Blood Pressure
Cognition - physiology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - drug therapy
Female
Humans
Hypertension - diagnosis
Hypertension - drug therapy
Hypotension
Male
Mental Status and Dementia Tests
Middle Aged
Neuropsychological Tests
Original
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Summary:Lowering of systolic blood pressure (SBP) in patients with low diastolic blood pressure (DBP), can further lower DBP. This can potentially decrease cerebral perfusion and cognition. We examined the influence of baseline DBP on the effect of lowering SBP on cognition. This is a post hoc analysis of the Memory in Diabetes (MIND) substudy (N = 1,430) of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study (NCT00000620). Standard neuropsychological tests (Digit Symbol Substitution Test [DSST], Mini-Mental State Examination [MMSE], Rey Auditory Verbal Learning Test [RAVLT], and Stroop test) were performed at baseline and months 20 and 40. We compared the effects of intensive (goal SBP
ISSN:0895-7061
1941-7225
DOI:10.1093/ajh/hpac118