Age, sex, and socioeconomic differences in multimorbidity measured in four ways: UK primary care cross-sectional analysis

• Published in: British journal of general practice 2023-04, Vol.73 (729), p.e249-e256
• Main Authors: MacRae, Clare, Mercer, Stewart W, Henderson, David, McMinn, Megan, Morales, Daniel R, Jefferson, Emily, Lyons, Ronan A, Lyons, Jane, Dibben, Chris, McAllister, David A, Guthrie, Bruce
• Format: Article
• Language: English
• Subjects: Comorbidity; Cross-Sectional Studies; Female; Humans; Mental health care; Morbidity; Multimorbidity; Prevalence; Primary care; Primary Health Care; Socioeconomic Factors; United Kingdom - epidemiology
• ISSN: 0960-1643; 1478-5242
• DOI: 10.3399/BJGP.2022.0405

Multimorbidity poses major challenges to healthcare systems worldwide. Definitions with cut-offs in excess of ≥2 long-term conditions (LTCs) might better capture populations with complexity but are not standardised. To examine variation in prevalence using different definitions of multimorbidity. Cross-sectional study of 1 168 620 people in England. Comparison of multimorbidity (MM) prevalence using four definitions: MM2+ (≥2 LTCs), MM3+ (≥3 LTCs), MM3+ from 3+ (≥3 LTCs from ≥3 International Classification of Diseases, 10th revision chapters), and mental-physical MM (≥2 LTCs where ≥1 mental health LTC and ≥1 physical health LTC are recorded). Logistic regression was used to examine patient characteristics associated with multimorbidity under all four definitions. MM2+ was most common (40.4%) followed by MM3+ (27.5%), MM3+ from 3+ (22.6%), and mental-physical MM (18.9%). MM2+, MM3+, and MM3+ from 3+ were strongly associated with oldest age (adjusted odds ratio [aOR] 58.09, 95% confidence interval [CI] = 56.13 to 60.14; aOR 77.69, 95% CI = 75.33 to 80.12; and aOR 102.06, 95% CI = 98.61 to 105.65; respectively), but mental-physical MM was much less strongly associated (aOR 4.32, 95% CI = 4.21 to 4.43). People in the most deprived decile had equivalent rates of multimorbidity at a younger age than those in the least deprived decile. This was most marked in mental-physical MM at 40-45 years younger, followed by MM2+ at 15-20 years younger, and MM3+ and MM3+ from 3+ at 10-15 years younger. Females had higher prevalence of multimorbidity under all definitions, which was most marked for mental-physical MM. Estimated prevalence of multimorbidity depends on the definition used, and associations with age, sex, and socioeconomic position vary between definitions. Applicable multimorbidity research requires consistency of definitions across studies.