Inflammatory Bowel Disease Risk Variants Are Associated with an Increased Risk of Skin Cancer

Abstract Background Inflammatory bowel disease is associated with an increased risk of skin cancer. The aims of this study were to determine whether IBD susceptibility variants are also associated with skin cancer susceptibility and if such risk is augmented by use of immune-suppressive therapy. Met...

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Published in:Inflammatory bowel diseases 2022-11, Vol.28 (11), p.1667-1676
Main Authors: Cushing, Kelly C, Du, Xiaomeng, Chen, Yanhua, Stetson, L C, Kuppa, Annapurna, Chen, Vincent L, Kahlenberg, J Michelle, Gudjonsson, Johann E, Vanderwerff, Brett, Higgins, Peter D R, Speliotes, Elizabeth K
Format: Article
Language:English
Subjects:
Basic-Leucine Zipper Transcription Factors
Clinical Research
Endothelial Protein C Receptor
Humans
Inflammatory Bowel Diseases - genetics
Melanoma, Cutaneous Malignant
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Risk Factors
RNA-Binding Proteins
Skin Neoplasms - genetics
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Summary:Abstract Background Inflammatory bowel disease is associated with an increased risk of skin cancer. The aims of this study were to determine whether IBD susceptibility variants are also associated with skin cancer susceptibility and if such risk is augmented by use of immune-suppressive therapy. Methods The discovery cohort included participants in the UK Biobank. The validation cohort included participants in the Michigan Genomics Initiative. The primary outcome of interest was skin cancer, subgrouped into nonmelanoma skin cancers (NMSC) and melanoma skin cancers (MSC). Multivariable logistic regression with matched controls (3 controls:1 case) was performed to identify genomic predictors of skin malignancy in the discovery cohort. Variants with P
ISSN:1078-0998
1536-4844
DOI:10.1093/ibd/izab336