Nonsteroidal anti-inflammatory drugs and implications for the cyclooxygenase pathway in embryonic development

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of analgesics that inhibit the activity of cyclooxygenase isoenzymes, which drive tissue inflammation pathways. Caution should be exercised when taking these drugs during pregnancy as they increase the risk of developmental defects. Due to th...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2023-02, Vol.324 (2), p.C532-C539
Main Authors: Leathers, Tess A, Rogers, Crystal D
Format: Article
Language:English
Subjects:
Analgesics
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Cyclooxygenase 2 - genetics
Drug development
Embryogenesis
Embryonic Development - drug effects
Female
Humans
Inflammation
Inflammation - drug therapy
Intrauterine exposure
Isoenzymes
Isoenzymes - antagonists & inhibitors
Mini-Review
Nonsteroidal anti-inflammatory drugs
Pregnancy
Prostaglandin endoperoxide synthase
Prostaglandin-Endoperoxide Synthases
Signal transduction
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Summary:Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of analgesics that inhibit the activity of cyclooxygenase isoenzymes, which drive tissue inflammation pathways. Caution should be exercised when taking these drugs during pregnancy as they increase the risk of developmental defects. Due to the high rates of NSAID use by individuals, possibilities for in utero exposure to NSAIDs are high, and it is vital that we define the potential risks these drugs pose during embryonic development. In this review, we characterize the identified roles of the cyclooxygenase signaling pathway components throughout pregnancy and discuss the effects of cyclooxygenase pathway perturbation on developmental outcomes.
ISSN:0363-6143
1522-1563
1522-1563
DOI:10.1152/ajpcell.00430.2022