Bidirectional temporal relationships between uric acid and insulin and their joint impact on incident diabetes

This study aims to examine the temporal relationship between uric acid (UA) and insulin and their joint impact on T2DM in middle-aged adults. The cohort consisted of 1351 non-diabetic adults who had serum UA and insulin measured twice at baseline and follow-up over 7.7 years on average, and incidenc...

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Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2023-02, Vol.33 (2), p.331-339
Main Authors: Yan, Yinkun, Wang, Xuan, Li, Shengxu, Sun, Dianjianyi, Fan, Lijun, Bazzano, Lydia, He, Jiang, Zhang, Tao, Chen, Wei
Format: Article
Language:English
Subjects:
Adult
blood serum
Diabetes
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Humans
Hyperinsulinism
hyperuricemia
Insulin
Insulin - adverse effects
Mediation effect
metabolism
Middle Aged
nutrition
Risk Factors
Temporal relationship
Uric Acid
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Summary:This study aims to examine the temporal relationship between uric acid (UA) and insulin and their joint impact on T2DM in middle-aged adults. The cohort consisted of 1351 non-diabetic adults who had serum UA and insulin measured twice at baseline and follow-up over 7.7 years on average, and incidence of T2DM in the outcome survey12.2 years later. After adjusting for covariates, the path coefficient from baseline UA to follow-up insulin was 0.082 (p 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2022.11.022