Long vs Short Acting Testosterone Treatments: A Look at the Risks

Prescriptions for testosterone therapy (TT) to treat testosterone deficiency have increased in recent years. The purpose of this review was to evaluate the risks of several treatment modalities to better counsel patients. Both short-acting and long-acting TT has been shown to restore normal serum te...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2023-02, Vol.172, p.5-12
Main Authors: Gurayah, Aaron A., Dullea, Alexandra, Weber, Alexander, Masterson, John M., Khodamoradi, Kajal, Mohamed, Arslan I., Ramasamy, Ranjith
Format: Article
Language:English
Subjects:
Hormone Replacement Therapy - adverse effects
Humans
Testosterone
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Summary:Prescriptions for testosterone therapy (TT) to treat testosterone deficiency have increased in recent years. The purpose of this review was to evaluate the risks of several treatment modalities to better counsel patients. Both short-acting and long-acting TT has been shown to restore normal serum testosterone levels and improve symptoms of testosterone deficiency. Short-acting pharmacology mimics normal physiology more closely than long-acting TT but requires multiple doses per day. Long-acting TT has a higher rate of patient adherence but is more likely to create supraphysiologic serum testosterone and pathologic sequelae.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2022.11.016