Magnetization transfer saturation reveals subclinical optic nerve injury in pediatric-onset multiple sclerosis

Background: The presence of subclinical optic nerve (ON) injury in youth living with pediatric-onset MS has not been fully elucidated. Magnetization transfer saturation (MTsat) is an advanced magnetic resonance imaging (MRI) parameter sensitive to myelin density and microstructural integrity, which...

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Bibliographic Details
Published in:Multiple sclerosis 2023-02, Vol.29 (2), p.212-220
Main Authors: Longoni, Giulia, Martinez Chavez, Edgar, Young, Kimberly, Brown, Robert A, Bells, Sonya, Fetco, Dumitru, Kim, Laura, Grover, Stephanie A, Costello, Fiona, Reginald, Arun, Bar-Or, Amit, Marrie, Ruth Ann, Arnold, Douglas L, Narayanan, Sridar, Branson, Helen M, Banwell, Brenda L., Sled, John G, Mabbott, Donald J., Yeh, E Ann
Format: Article
Language:English
Subjects:
Adolescent
Child
Evoked Potentials, Visual
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetoencephalography
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - diagnostic imaging
Myelin
Neuritis
Neuroimaging
Optic nerve
Optic Nerve - diagnostic imaging
Optic Nerve Injuries - complications
Optic Neuritis
Original Research Papers
Pediatrics
Structure-function relationships
Substantia alba
Tomography, Optical Coherence - methods
Visual evoked potentials
Visual pathways
Visual perception
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Summary:Background: The presence of subclinical optic nerve (ON) injury in youth living with pediatric-onset MS has not been fully elucidated. Magnetization transfer saturation (MTsat) is an advanced magnetic resonance imaging (MRI) parameter sensitive to myelin density and microstructural integrity, which can be applied to the study of the ON. Objective: The objective of this study was to investigate the presence of subclinical ON abnormalities in pediatric-onset MS by means of magnetization transfer saturation and evaluate their association with other structural and functional parameters of visual pathway integrity. Methods: Eleven youth living with pediatric-onset MS (ylPOMS) and no previous history of optic neuritis and 18 controls underwent standardized brain MRI, optical coherence tomography (OCT), Magnetoencephalography (MEG)-Visual Evoked Potentials (VEPs), and visual battery. Data were analyzed with mixed effect models. Results: While ON volume, OCT parameters, occipital MEG-VEPs outcomes, and visual function did not differ significantly between ylPOMS and controls, ylPOMS had lower MTsat in the supratentorial normal appearing white matter (−0.26 nU, p = 0.0023), and in both in the ON (−0.62 nU, p 
ISSN:1352-4585
1477-0970
DOI:10.1177/13524585221137500