Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity

Conjugates of the natural alkaloid (a R ,7 S )-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic propertie...

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Bibliographic Details
Published in:Russian chemical bulletin 2023, Vol.72 (1), p.248-262
Main Authors: Shchegravina, E. S., Usova, S. D., Baev, D. S., Mozhaitsev, E. S., Shcherbakov, D. N., Belenkaya, S. V., Volosnikova, E. A., Chirkova, V. Yu, Sharlaeva, E. A., Svirshchevskaya, E. V., Fonareva, I. P., Sitdikova, A. R., Salakhutdinov, N. F., Yarovaya, O. I., Fedorov, A. Yu
Format: Article
Language:English
Subjects:
Biological activity
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Colchicine
Conjugates
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Inorganic Chemistry
Molecular docking
Organic Chemistry
Protease
Viral diseases
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Summary:Conjugates of the natural alkaloid (a R ,7 S )-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-023-3730-4