Loading…
Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity
Conjugates of the natural alkaloid (a R ,7 S )-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic propertie...
Saved in:
| Published in: | Russian chemical bulletin 2023, Vol.72 (1), p.248-262 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c400t-7b5516715bcaed4f2210793e4ae72ba407aeb944c7a745085994edc2d16d7b3b3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c400t-7b5516715bcaed4f2210793e4ae72ba407aeb944c7a745085994edc2d16d7b3b3 |
| container_end_page | 262 |
| container_issue | 1 |
| container_start_page | 248 |
| container_title | Russian chemical bulletin |
| container_volume | 72 |
| creator | Shchegravina, E. S. Usova, S. D. Baev, D. S. Mozhaitsev, E. S. Shcherbakov, D. N. Belenkaya, S. V. Volosnikova, E. A. Chirkova, V. Yu Sharlaeva, E. A. Svirshchevskaya, E. V. Fonareva, I. P. Sitdikova, A. R. Salakhutdinov, N. F. Yarovaya, O. I. Fedorov, A. Yu |
| description | Conjugates of the natural alkaloid (a
R
,7
S
)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied. |
| doi_str_mv | 10.1007/s11172-023-3730-4 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9926439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2776661709</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-7b5516715bcaed4f2210793e4ae72ba407aeb944c7a745085994edc2d16d7b3b3</originalsourceid><addsrcrecordid>eNp1kV1rFDEYhYMo9kN_gDcy4E0FU_P9ztwUpFgVCgWr1yGTye5mmU3WJLOy_95Mt1YteJWE85yT9-Ug9IqSc0oIvM-UUmCYMI45cILFE3RMJXDcUaBP650ohSVr5RE6yXlNCGFt2z5HR1y1FKSEY7S93YeyctnnJi4aG8N6Wpri7l5n5us7uH2LbRztylsfXPPTl1WziSEWl7YuRD_kxoSh8WHncvHV6mOYvTXTp6b3cYxLb83YGFv8zpf9C_RsYcbsXt6fp-j71cdvl5_x9c2nL5cfrrEVhBQMvZRUAZW9NW4QC8YogY47YRyw3ggCxvWdEBYMCEla2XXCDZYNVA3Q856footD7nbqN1VxoSQz6m3yG5P2Ohqv_1WCX-ll3OmuY0rwrgac3Qek-GOq2-mNz9aNowkuTlkzqPMIAUpV9M0jdB2nFOp6M6WUokDmQHqgbIo5J7d4GIYSPfepD33q2qee-9Siel7_vcWD43eBFWAHIFcpLF368_X_U38BPnqtFQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2776661709</pqid></control><display><type>article</type><title>Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity</title><source>Springer Nature</source><creator>Shchegravina, E. S. ; Usova, S. D. ; Baev, D. S. ; Mozhaitsev, E. S. ; Shcherbakov, D. N. ; Belenkaya, S. V. ; Volosnikova, E. A. ; Chirkova, V. Yu ; Sharlaeva, E. A. ; Svirshchevskaya, E. V. ; Fonareva, I. P. ; Sitdikova, A. R. ; Salakhutdinov, N. F. ; Yarovaya, O. I. ; Fedorov, A. Yu</creator><creatorcontrib>Shchegravina, E. S. ; Usova, S. D. ; Baev, D. S. ; Mozhaitsev, E. S. ; Shcherbakov, D. N. ; Belenkaya, S. V. ; Volosnikova, E. A. ; Chirkova, V. Yu ; Sharlaeva, E. A. ; Svirshchevskaya, E. V. ; Fonareva, I. P. ; Sitdikova, A. R. ; Salakhutdinov, N. F. ; Yarovaya, O. I. ; Fedorov, A. Yu</creatorcontrib><description>Conjugates of the natural alkaloid (a
R
,7
S
)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.</description><identifier>ISSN: 1066-5285</identifier><identifier>EISSN: 1573-9171</identifier><identifier>DOI: 10.1007/s11172-023-3730-4</identifier><identifier>PMID: 36817557</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biological activity ; Chemical synthesis ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Colchicine ; Conjugates ; Full ; Full Articles ; Inorganic Chemistry ; Molecular docking ; Organic Chemistry ; Protease ; Viral diseases</subject><ispartof>Russian chemical bulletin, 2023, Vol.72 (1), p.248-262</ispartof><rights>Springer Science+Business Media LLC 2023</rights><rights>Springer Science+Business Media LLC 2023.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-7b5516715bcaed4f2210793e4ae72ba407aeb944c7a745085994edc2d16d7b3b3</citedby><cites>FETCH-LOGICAL-c400t-7b5516715bcaed4f2210793e4ae72ba407aeb944c7a745085994edc2d16d7b3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36817557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shchegravina, E. S.</creatorcontrib><creatorcontrib>Usova, S. D.</creatorcontrib><creatorcontrib>Baev, D. S.</creatorcontrib><creatorcontrib>Mozhaitsev, E. S.</creatorcontrib><creatorcontrib>Shcherbakov, D. N.</creatorcontrib><creatorcontrib>Belenkaya, S. V.</creatorcontrib><creatorcontrib>Volosnikova, E. A.</creatorcontrib><creatorcontrib>Chirkova, V. Yu</creatorcontrib><creatorcontrib>Sharlaeva, E. A.</creatorcontrib><creatorcontrib>Svirshchevskaya, E. V.</creatorcontrib><creatorcontrib>Fonareva, I. P.</creatorcontrib><creatorcontrib>Sitdikova, A. R.</creatorcontrib><creatorcontrib>Salakhutdinov, N. F.</creatorcontrib><creatorcontrib>Yarovaya, O. I.</creatorcontrib><creatorcontrib>Fedorov, A. Yu</creatorcontrib><title>Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity</title><title>Russian chemical bulletin</title><addtitle>Russ Chem Bull</addtitle><addtitle>Russ Chem Bull</addtitle><description>Conjugates of the natural alkaloid (a
R
,7
S
)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.</description><subject>Biological activity</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Colchicine</subject><subject>Conjugates</subject><subject>Full</subject><subject>Full Articles</subject><subject>Inorganic Chemistry</subject><subject>Molecular docking</subject><subject>Organic Chemistry</subject><subject>Protease</subject><subject>Viral diseases</subject><issn>1066-5285</issn><issn>1573-9171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kV1rFDEYhYMo9kN_gDcy4E0FU_P9ztwUpFgVCgWr1yGTye5mmU3WJLOy_95Mt1YteJWE85yT9-Ug9IqSc0oIvM-UUmCYMI45cILFE3RMJXDcUaBP650ohSVr5RE6yXlNCGFt2z5HR1y1FKSEY7S93YeyctnnJi4aG8N6Wpri7l5n5us7uH2LbRztylsfXPPTl1WziSEWl7YuRD_kxoSh8WHncvHV6mOYvTXTp6b3cYxLb83YGFv8zpf9C_RsYcbsXt6fp-j71cdvl5_x9c2nL5cfrrEVhBQMvZRUAZW9NW4QC8YogY47YRyw3ggCxvWdEBYMCEla2XXCDZYNVA3Q856footD7nbqN1VxoSQz6m3yG5P2Ohqv_1WCX-ll3OmuY0rwrgac3Qek-GOq2-mNz9aNowkuTlkzqPMIAUpV9M0jdB2nFOp6M6WUokDmQHqgbIo5J7d4GIYSPfepD33q2qee-9Siel7_vcWD43eBFWAHIFcpLF368_X_U38BPnqtFQ</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Shchegravina, E. S.</creator><creator>Usova, S. D.</creator><creator>Baev, D. S.</creator><creator>Mozhaitsev, E. S.</creator><creator>Shcherbakov, D. N.</creator><creator>Belenkaya, S. V.</creator><creator>Volosnikova, E. A.</creator><creator>Chirkova, V. Yu</creator><creator>Sharlaeva, E. A.</creator><creator>Svirshchevskaya, E. V.</creator><creator>Fonareva, I. P.</creator><creator>Sitdikova, A. R.</creator><creator>Salakhutdinov, N. F.</creator><creator>Yarovaya, O. I.</creator><creator>Fedorov, A. Yu</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2023</creationdate><title>Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity</title><author>Shchegravina, E. S. ; Usova, S. D. ; Baev, D. S. ; Mozhaitsev, E. S. ; Shcherbakov, D. N. ; Belenkaya, S. V. ; Volosnikova, E. A. ; Chirkova, V. Yu ; Sharlaeva, E. A. ; Svirshchevskaya, E. V. ; Fonareva, I. P. ; Sitdikova, A. R. ; Salakhutdinov, N. F. ; Yarovaya, O. I. ; Fedorov, A. Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-7b5516715bcaed4f2210793e4ae72ba407aeb944c7a745085994edc2d16d7b3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biological activity</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Colchicine</topic><topic>Conjugates</topic><topic>Full</topic><topic>Full Articles</topic><topic>Inorganic Chemistry</topic><topic>Molecular docking</topic><topic>Organic Chemistry</topic><topic>Protease</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shchegravina, E. S.</creatorcontrib><creatorcontrib>Usova, S. D.</creatorcontrib><creatorcontrib>Baev, D. S.</creatorcontrib><creatorcontrib>Mozhaitsev, E. S.</creatorcontrib><creatorcontrib>Shcherbakov, D. N.</creatorcontrib><creatorcontrib>Belenkaya, S. V.</creatorcontrib><creatorcontrib>Volosnikova, E. A.</creatorcontrib><creatorcontrib>Chirkova, V. Yu</creatorcontrib><creatorcontrib>Sharlaeva, E. A.</creatorcontrib><creatorcontrib>Svirshchevskaya, E. V.</creatorcontrib><creatorcontrib>Fonareva, I. P.</creatorcontrib><creatorcontrib>Sitdikova, A. R.</creatorcontrib><creatorcontrib>Salakhutdinov, N. F.</creatorcontrib><creatorcontrib>Yarovaya, O. I.</creatorcontrib><creatorcontrib>Fedorov, A. Yu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Russian chemical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shchegravina, E. S.</au><au>Usova, S. D.</au><au>Baev, D. S.</au><au>Mozhaitsev, E. S.</au><au>Shcherbakov, D. N.</au><au>Belenkaya, S. V.</au><au>Volosnikova, E. A.</au><au>Chirkova, V. Yu</au><au>Sharlaeva, E. A.</au><au>Svirshchevskaya, E. V.</au><au>Fonareva, I. P.</au><au>Sitdikova, A. R.</au><au>Salakhutdinov, N. F.</au><au>Yarovaya, O. I.</au><au>Fedorov, A. Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity</atitle><jtitle>Russian chemical bulletin</jtitle><stitle>Russ Chem Bull</stitle><addtitle>Russ Chem Bull</addtitle><date>2023</date><risdate>2023</risdate><volume>72</volume><issue>1</issue><spage>248</spage><epage>262</epage><pages>248-262</pages><issn>1066-5285</issn><eissn>1573-9171</eissn><abstract>Conjugates of the natural alkaloid (a
R
,7
S
)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36817557</pmid><doi>10.1007/s11172-023-3730-4</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1066-5285 |
| ispartof | Russian chemical bulletin, 2023, Vol.72 (1), p.248-262 |
| issn | 1066-5285 1573-9171 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9926439 |
| source | Springer Nature |
| subjects | Biological activity Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Colchicine Conjugates Full Full Articles Inorganic Chemistry Molecular docking Organic Chemistry Protease Viral diseases |
| title | Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T02%3A22%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20of%20conjugates%20of%20(aR,7S)-colchicine%20with%20monoterpenoids%20and%20investigation%20of%20their%20biological%20activity&rft.jtitle=Russian%20chemical%20bulletin&rft.au=Shchegravina,%20E.%20S.&rft.date=2023&rft.volume=72&rft.issue=1&rft.spage=248&rft.epage=262&rft.pages=248-262&rft.issn=1066-5285&rft.eissn=1573-9171&rft_id=info:doi/10.1007/s11172-023-3730-4&rft_dat=%3Cproquest_pubme%3E2776661709%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c400t-7b5516715bcaed4f2210793e4ae72ba407aeb944c7a745085994edc2d16d7b3b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2776661709&rft_id=info:pmid/36817557&rfr_iscdi=true |