Pain-Related Gene Solute Carrier Family 24 Member 3 Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma: A Study via Integrated Bioinformatics Analyses and Experimental Verification

The aim of this study was to explore cervical carcinoma and screen a suitable gene as the biomarker used for prognosis evaluation as well as pain therapy. Low expression levels of solute carrier family 24 member 3 (SLC24A3) was involved in the appearance and development of numerous malignancies. Nev...

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Published in:Computational and mathematical methods in medicine 2023, Vol.2023 (1), p.4164232-4164232
Main Authors: Zhou, Shuguang, Jin, Qinqin, Yao, Hui, Ying, Jie, Tian, Lu, Jiang, Xiya, Yang, Yinting, Jiang, Xiaomin, Gao, Wei, Zhang, Weiyu, Zhu, Yuting, Cao, Wujun
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Bone Neoplasms
Breast Neoplasms
Carcinoma, Squamous Cell - genetics
Computational Biology
Female
Humans
Pain
Prognosis
Uterine Cervical Neoplasms - genetics
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Summary:The aim of this study was to explore cervical carcinoma and screen a suitable gene as the biomarker used for prognosis evaluation as well as pain therapy. Low expression levels of solute carrier family 24 member 3 (SLC24A3) was involved in the appearance and development of numerous malignancies. Nevertheless, the prognostic value of SLC24A3 expression with cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) patients remains uncertain. During the present study, SLC24A3 expression in CESC was retrieved from TCGA, GEO, and MSigDB databases. Based on TCGA and GEO profiles, we performed survival and difference analyses about SLC24A3 both in two GEO (GSE44001 and GSE63514) and TCGA-CESC cohorts (all p
ISSN:1748-670X
1748-6718
DOI:10.1155/2023/4164232