Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel

Plants obtain nutrients from the soil via transmembrane transporters and channels in their root hairs, from which ions radially transport in toward the xylem for distribution across the plant body. We determined structures of the hyperpolarization-activated channel AKT1 from Arabidopsis thaliana, wh...

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Bibliographic Details
Published in:Biochemistry (Easton) 2022-10, Vol.61 (20), p.2177-2181
Main Authors: Dickinson, Miles Sasha, Pourmal, Sergei, Gupta, Meghna, Bi, Maxine, Stroud, Robert M.
Format: Article
Language:English
Subjects:
Arabidopsis - metabolism
Arabidopsis Proteins - metabolism
Gene Expression Regulation, Plant
Ion Channels
Lipids
Potassium - metabolism
Potassium Channels - genetics
Soil
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Summary:Plants obtain nutrients from the soil via transmembrane transporters and channels in their root hairs, from which ions radially transport in toward the xylem for distribution across the plant body. We determined structures of the hyperpolarization-activated channel AKT1 from Arabidopsis thaliana, which mediates K+ uptake from the soil into plant roots. These structures of AtAKT1 embedded in lipid nanodiscs show that the channel undergoes a reduction of C4 to C2 symmetry, possibly to regulate its electrical activation.
ISSN:0006-2960
1520-4995
DOI:10.1021/acs.biochem.1c00654