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Prospective evaluation of radiographic manifestations of tuberculosis in relationship with CD4 count in patients with HIV/AIDS

A major risk factor to develop active tuberculosis (TB) is the infection with the human immunodeficiency virus (HIV). Chest radiography is the first-line imaging modality used to rule out TB. Coinfected individuals present often with atypical imaging patterns, due to the immunosuppression caused by...

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Bibliographic Details
Published in:Medicine (Baltimore) 2023-02, Vol.102 (7), p.e32917-e32917
Main Authors: Frey, Vanessa, Phi Van, Valerie Doan, Fehr, Jan S, Ledergerber, Bruno, Sekaggya-Wiltshire, Christine, Castelnuovo, Barbara, Kambugu, Andrew, Bauer, Max, Eberhard, Nadja, Martini, Katharina, Frauenfelder, Thomas
Format: Article
Language:English
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Summary:A major risk factor to develop active tuberculosis (TB) is the infection with the human immunodeficiency virus (HIV). Chest radiography is the first-line imaging modality used to rule out TB. Coinfected individuals present often with atypical imaging patterns, due to the immunosuppression caused by the virus, making diagnosis difficult. In this prospective observational study 268 TB and HIV coinfected patients were included. During a follow-up period of 24 weeks, the predominant patterns on chest radiography were analyzed and compared to the cluster of differentiation 4 (CD4) count under antiretroviral and anti-TB therapy. Patients with low CD4 counts (
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000032917