Tissue levels of suppressor of cytokine signaling-3 (SOCS-3) in mycosis fungoides

Mycosis fungoides (MF) is a type of cutaneous T-cell lymphoma with proposed multifactorial etiology. Suppressor of cytokine signaling-3 (SOCS-3) is one of the proteins expressed in MF. Its exact role in disease pathogenesis has not yet been thoroughly investigated. This study aimed to assess the exp...

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Bibliographic Details
Published in:Archives of Dermatological Research 2023-03, Vol.315 (2), p.165-171
Main Authors: Nada, Hanan R., Rashed, Laila A., Salman, Ola Ouda, Abdallah, Nermeen M. A., Abdelhady, Mohamed M.
Format: Article
Language:English
Subjects:
Cytokines
Dermatology
Etiology
Fungal infections
Humans
Lymphocytes T
Medicine
Medicine & Public Health
Mycosis
Mycosis fungoides
Mycosis Fungoides - pathology
Original Paper
Pathogenesis
Patients
Pruritus
Skin - pathology
Skin Neoplasms - pathology
Statistical analysis
T-cell lymphoma
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Summary:Mycosis fungoides (MF) is a type of cutaneous T-cell lymphoma with proposed multifactorial etiology. Suppressor of cytokine signaling-3 (SOCS-3) is one of the proteins expressed in MF. Its exact role in disease pathogenesis has not yet been thoroughly investigated. This study aimed to assess the expression of SOCS-3 in patients’ skin with mycosis fungoides to elucidate their possible role in the pathogenesis in MF. 30 patients with mycosis fungoides and 30 age and sex-matched healthy controls were included. After clinical examination, tissue levels of SOCS-3 were measured by ELISA. The level of expression of SOCS-3 was significantly upregulated in the lesional tissue compared to perilesional SOCS-3 level in patients’ group ( P  
ISSN:1432-069X
0340-3696
1432-069X
DOI:10.1007/s00403-022-02339-x