Spirocitrinols A and B, citrinin derivatives with a spiro[chromane-2,3'-isochromane] skeleton from Penicillium citrinum

Spirocitrinols A (1) and B (2), two new citrinin-derived metabolites possessing a spiro[chromane-2,3'-isochromane] skeleton, were isolated from cultures of . Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2 were assigned by electronic circula...

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Bibliographic Details
Published in:RSC advances 2023-02, Vol.13 (9), p.6124-6129
Main Authors: Tong, Junjie, Zhang, Yang, Xu, Yang, Han, Yangyang, Li, Chuan, Zhuang, Wenying, Che, Yongsheng
Format: Article
Language:English
Subjects:
Chemistry
Dichroism
Fungi
Metabolites
NMR
Nuclear magnetic resonance
Toxicity
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Summary:Spirocitrinols A (1) and B (2), two new citrinin-derived metabolites possessing a spiro[chromane-2,3'-isochromane] skeleton, were isolated from cultures of . Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2 were assigned by electronic circular dichroism calculations. Compound 2 is the first naturally occurring trimeric citrinin derivative with a spiro[chromane-2,3'-isochromane] core. Compound 1 showed modest cytotoxicity against A549 human tumor cells.
ISSN:2046-2069
2046-2069
DOI:10.1039/d3ra00665d