Spontaneous cortical dynamics from the first years to the golden years

In the largest and most expansive lifespan magnetoencephalography (MEG) study to date (n = 434, 6 to 84 y), we provide critical data on the normative trajectory of resting-state spontaneous activity and its temporal dynamics. We perform cutting-edge analyses to examine age and sex effects on whole-b...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2023-01, Vol.120 (4), p.e2212776120-e2212776120
Main Authors: Rempe, Maggie P, Ott, Lauren R, Picci, Giorgia, Penhale, Samantha H, Christopher-Hayes, Nicholas J, Lew, Brandon J, Petro, Nathan M, Embury, Christine M, Schantell, Mikki, Johnson, Hallie J, Okelberry, Hannah J, Losh, Kathryn L, Willett, Madelyn P, Losh, Rebecca A, Wang, Yu-Ping, Calhoun, Vince D, Stephen, Julia M, Heinrichs-Graham, Elizabeth, Kurz, Max J, Wilson, Tony W
Format: Article
Language:English
Subjects:
Age
Biological Sciences
Brain
Brain Mapping
Correlation
Life span
Longevity
Magnetoencephalography
Sex
Spectral bands
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the largest and most expansive lifespan magnetoencephalography (MEG) study to date (n = 434, 6 to 84 y), we provide critical data on the normative trajectory of resting-state spontaneous activity and its temporal dynamics. We perform cutting-edge analyses to examine age and sex effects on whole-brain, spatially-resolved relative and absolute power maps, and find significant age effects in all spectral bands in both types of maps. Specifically, lower frequencies showed a negative correlation with age, while higher frequencies positively correlated with age. These correlations were further probed with hierarchical regressions, which revealed significant nonlinear trajectories in key brain regions. Sex effects were found in absolute but not relative power maps, highlighting key differences between outcome indices that are generally used interchangeably. Our rigorous and innovative approach provides multispectral maps indicating the unique trajectory of spontaneous neural activity across the lifespan, and illuminates key methodological considerations with the widely used relative/absolute power maps of spontaneous cortical dynamics.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2212776120