Viral-host interactions during splicing and nuclear export of influenza virus mRNAs

As influenza-A viruses (IAV) replicate in the host cell nucleus, intranuclear pathways are usurped for viral gene expression. The eight genomic viral ribonucleoproteins (vRNPs) segments of IAV are transcribed and two generate viral mRNAs (M and NS) that undergo alternative splicing followed by expor...

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Bibliographic Details
Published in:Current opinion in virology 2022-08, Vol.55, p.101254-101254, Article 101254
Main Authors: Esparza, Matthew, Bhat, Prasanna, Fontoura, Beatriz Ma
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Cell Nucleus
Host Microbial Interactions
Influenza A virus - genetics
RNA Splicing
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA, Viral - genetics
Virus Replication
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Summary:As influenza-A viruses (IAV) replicate in the host cell nucleus, intranuclear pathways are usurped for viral gene expression. The eight genomic viral ribonucleoproteins (vRNPs) segments of IAV are transcribed and two generate viral mRNAs (M and NS) that undergo alternative splicing followed by export from the nucleus. The focus of this review is on viral RNA splicing and nuclear export. Recent mechanistic advances on M and NS splicing show differential regulation by RNA-binding proteins as well as distinct intranuclear localization. After a review of IAV splicing, we will discuss the nuclear export of viral mRNAs, which occur by interacting with specific constituents of the host mRNA export machinery that translocate viral mRNAs through the nuclear pore complex for translation in the cytoplasm.
ISSN:1879-6257
1879-6265
DOI:10.1016/j.coviro.2022.101254