The Roles of TRAF3 in Immune Responses

Seven tumor necrosis factor receptor- (TNFR-) associated factors (TRAFs) have been found in mammals, which are primarily involved in the signal translation of the TNFR superfamily, the Toll-like receptor (TLR) family, and the retinoic acid-inducible gene I- (RIG-I-) like receptor (RLR) family. TRAF3...

Full description

Saved in:
Bibliographic Details
Published in:Disease markers 2023, Vol.2023, p.7787803-11
Main Authors: Lin, Mengjiao, Ji, Xiaoli, Lv, Yan, Cui, Dawei, Xie, Jue
Format: Article
Language:English
Subjects:
Amino acids
Apoptosis
Cytokines
Immune response
Immune system
Interferon
Kinases
MAP kinase
Mutation
Physiology
Proteins
Regulatory mechanisms (biology)
Retinoic acid
Review
Signal transduction
Signaling
Toll-like receptors
Tumor necrosis factor receptors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Seven tumor necrosis factor receptor- (TNFR-) associated factors (TRAFs) have been found in mammals, which are primarily involved in the signal translation of the TNFR superfamily, the Toll-like receptor (TLR) family, and the retinoic acid-inducible gene I- (RIG-I-) like receptor (RLR) family. TRAF3 is one of the most diverse members of the TRAF family. It can positively regulate type I interferon production while negatively regulating signaling pathways of classical nuclear factor-κB, nonclassical nuclear factor-κB, and mitogen-activated protein kinase (MAPK). This review summarizes the roles of TRAF3 signaling and the related immune receptors (e.g., TLRs) in several preclinical and clinical diseases and focuses on the roles of TRAF3 in immune responses, the regulatory mechanisms, and its role in disease.
ISSN:0278-0240
1875-8630
DOI:10.1155/2023/7787803