Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants

Host organisms utilise a range of genetically encoded cell death programmes in response to pathogen challenge. Host cell death can restrict pathogen proliferation by depleting their replicative niche and at the same time dying cells can alert neighbouring cells to prepare environmental conditions fa...

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Bibliographic Details
Published in:Cell death and differentiation 2023-02, Vol.30 (2), p.258-268
Main Authors: Maekawa, Takaki, Kashkar, Hamid, Coll, Núria S.
Format: Article
Language:English
Subjects:
631/250/1932
631/326
Animals
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Cycle Analysis
Cell death
Defense mechanisms
Environmental conditions
Host plants
Host-Pathogen Interactions
Hypersensitive response
Immunogenic Cell Death
Immunogenicity
Life Sciences
Pathogens
Plants - metabolism
Review
Review Article
Signal Transduction - physiology
Stem Cells
Virulence
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Summary:Host organisms utilise a range of genetically encoded cell death programmes in response to pathogen challenge. Host cell death can restrict pathogen proliferation by depleting their replicative niche and at the same time dying cells can alert neighbouring cells to prepare environmental conditions favouring future pathogen attacks. As expected, many pathogenic microbes have strategies to subvert host cell death to promote their virulence. The structural and lifestyle differences between animals and plants have been anticipated to shape very different host defence mechanisms. However, an emerging body of evidence indicates that several components of the host–pathogen interaction machinery are shared between the two major branches of eukaryotic life. Many proteins involved in cell death execution or cell death-associated immunity in plants and animals exert direct effects on endomembrane and loss of membrane integrity has been proposed to explain the potential immunogenicity of dying cells. In this review we aim to provide a comparative view on how cell death processes are linked to anti-microbial defence mechanisms in plants and animals and how pathogens interfere with these cell death programmes. In comparison to the several well-defined cell death programmes in animals, immunogenic cell death in plant defence is broadly defined as the hypersensitive response. Our comparative overview may help discerning whether specific types of immunogenic cell death exist in plants, and correspondingly, it may provide new hints for previously undiscovered cell death mechanism in animals.
ISSN:1350-9047
1476-5403
DOI:10.1038/s41418-022-01060-6