Angiotensin (1-7) Delivered Orally via Probiotic in Combination With Exercise: Sex-Dependent Influence on Health Span

Age-related declines in physical and cognitive function can have tremendous, negative impacts on health span and quality of life. Therefore, we investigated the potential of utilizing a probiotic treatment to target the renin-angiotensin system (RAS) in conjunction with moderate exercise to ameliora...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2023-02, Vol.78 (2), p.223-226
Main Authors: Hernandez, Abbi, Sun, Yi, Banerjee, Anisha, Yang, YouFeng, Verma, Amrisha, Li, Qiuhong, Baptista, Liliana, Buford, Thomas W, Carter, Christy S
Format: Article
Language:English
Subjects:
Age
Aging
Angiotensin
Angiotensin I
Angiotensin II
Animals
Cognitive ability
Exercise
Female
Health
Peptide Fragments
Probiotics
Quality of Life
Rats
Renin
Renin-Angiotensin System - physiology
THE JOURNAL OF GERONTOLOGY: Biological Sciences
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Summary:Age-related declines in physical and cognitive function can have tremendous, negative impacts on health span and quality of life. Therefore, we investigated the potential of utilizing a probiotic treatment to target the renin-angiotensin system (RAS) in conjunction with moderate exercise to ameliorate age-related declines in cognitive and physical function in aged rats. Herein we utilized a genetically modified angiotensin (1-7), which activates a "complementary" arm of the RAS through binding Mas (AT7) receptors. This process induces several beneficial physiologic effects, including decreased inflammation and enhanced physical/cognitive function. Thus, in this short research report, we suggest the efficacy of this Ang(1-7) releasing Lactobacillus paracasei (LPA) as either an alternative strategy to exercise, or more likely as an adjuvant to moderate exercise, for the prevention of both physical and cognitive decline especially in female rats.
ISSN:1079-5006
1758-535X
1758-535X
DOI:10.1093/gerona/glac198