Stereotactic Body Radiotherapy versus Surgery for Lung Metastases from Colorectal Cancer: Single-Institution Results

Surgery and stereotactic body radiotherapy (SBRT) are two of the options available as local treatments for pulmonary oligometastases from colorectal cancer (CRC). We hypothesized that SBRT would have, at least, a similar local control rate to surgery. We identified an initial cohort of 100 patients...

Full description

Saved in:
Bibliographic Details
Published in:Cancers 2023-02, Vol.15 (4), p.1195
Main Authors: Garcia-Exposito, Nagore, Ramos, Ricard, Navarro-Perez, Valentin, Molina, Kevin, Arnaiz, Maria Dolores, Padrones, Susana, Ruffinelli, Jose Carlos, Santos, Cristina, Guedea, Ferran, Navarro-Martin, Arturo
Format: Article
Language:English
Subjects:
Cancer therapies
Care and treatment
Colorectal cancer
Colorectal carcinoma
Comparative analysis
Liver diseases
Lung cancer
Lungs
Malignancy
Metastases
Metastasis
Patients
Radiation therapy
Radiosurgery
Surgery
Survival
Thorax
Tomography
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Surgery and stereotactic body radiotherapy (SBRT) are two of the options available as local treatments for pulmonary oligometastases from colorectal cancer (CRC). We hypothesized that SBRT would have, at least, a similar local control rate to surgery. We identified an initial cohort of 100 patients with CRC who received SBRT or surgery for lung metastases. This was then narrowed down to 75 patients: those who underwent surgery (n = 50) or SBRT (n = 25) as their first local thoracic treatment between 1 January 2004 and 29 December 2017. The Kaplan-Meier method was used to calculate lung-progression-free survival (L-PFS) and overall survival (OS). The 1 and 2-year L-PFS was 85% and 70% in the surgical group and 87% and 71% in the SBRT group, respectively ( = 0.809). No significant differences were found between the two groups in terms of OS. The biologically effective dose (BED), age and initial CRC stage did not have a significant effect on local control or survival. No grade 3 or above acute- or late-toxicity events were reported. These results add retrospective evidence that SBRT and surgery have similar results in terms of OS and local control in patients with lung oligometastases from CRC.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15041195