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Telomere Fragility and MiDAS: Managing the Gaps at the End of the Road
Telomeres present inherent difficulties to the DNA replication machinery due to their repetitive sequence content, formation of non-B DNA secondary structures, and the presence of the nucleo-protein t-loop. Especially in cancer cells, telomeres are hot spots for replication stress, which can result...
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Published in: | Genes 2023-01, Vol.14 (2), p.348 |
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description | Telomeres present inherent difficulties to the DNA replication machinery due to their repetitive sequence content, formation of non-B DNA secondary structures, and the presence of the nucleo-protein t-loop. Especially in cancer cells, telomeres are hot spots for replication stress, which can result in a visible phenotype in metaphase cells termed "telomere fragility". A mechanism cells employ to mitigate replication stress, including at telomeres, is DNA synthesis in mitosis (MiDAS). While these phenomena are both observed in mitotic cells, the relationship between them is poorly understood; however, a common link is DNA replication stress. In this review, we will summarize what is known to regulate telomere fragility and telomere MiDAS, paying special attention to the proteins which play a role in these telomere phenotypes. |
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Especially in cancer cells, telomeres are hot spots for replication stress, which can result in a visible phenotype in metaphase cells termed "telomere fragility". A mechanism cells employ to mitigate replication stress, including at telomeres, is DNA synthesis in mitosis (MiDAS). While these phenomena are both observed in mitotic cells, the relationship between them is poorly understood; however, a common link is DNA replication stress. In this review, we will summarize what is known to regulate telomere fragility and telomere MiDAS, paying special attention to the proteins which play a role in these telomere phenotypes.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes14020348</identifier><identifier>PMID: 36833275</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Cancer ; Deoxyribonucleic acid ; DNA ; DNA - metabolism ; DNA biosynthesis ; DNA polymerase ; DNA Replication ; DNA synthesis ; Genetic aspects ; Genotype & phenotype ; Kinases ; Metaphase ; Mitosis ; Mutation ; Nucleotide sequence ; Phenotype ; Phenotypes ; Physiological aspects ; Replication ; Review ; Telomerase ; Telomere - metabolism ; Telomeres ; Yeast</subject><ispartof>Genes, 2023-01, Vol.14 (2), p.348</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. 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subjects | Cancer Deoxyribonucleic acid DNA DNA - metabolism DNA biosynthesis DNA polymerase DNA Replication DNA synthesis Genetic aspects Genotype & phenotype Kinases Metaphase Mitosis Mutation Nucleotide sequence Phenotype Phenotypes Physiological aspects Replication Review Telomerase Telomere - metabolism Telomeres Yeast |
title | Telomere Fragility and MiDAS: Managing the Gaps at the End of the Road |
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