Nutritional Approaches to Modulate Cardiovascular Disease Risk in Systemic Lupus Erythematosus: A Literature Review

Systemic lupus erythematosus (SLE) is a chronic pathology characterized by a bimodal mortality pattern attributed to clinical disease activity and cardiovascular disease (CVD). A complex interaction between traditional CVD risk factors such as obesity, dyslipidemia, smoking, insulin resistance, meta...

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Bibliographic Details
Published in:Nutrients 2023-02, Vol.15 (4), p.1036
Main Authors: Pesqueda-Cendejas, Karen, Rivera-Escoto, Melissa, Meza-Meza, Mónica R, Campos-López, Bertha, Parra-Rojas, Isela, Montoya-Buelna, Margarita, De la Cruz-Mosso, Ulises
Format: Article
Language:English
Subjects:
Autoimmune diseases
C-reactive protein
Cardiovascular disease
Cardiovascular diseases
Chronic conditions
Comorbidity
Complications and side effects
Diet therapy
Dyslipidemia
Environmental factors
Health risks
Hyperhomocysteinemia
Hypertension
Immunomodulation
Immunomodulators
Inflammation
Insulin
Insulin resistance
Literature reviews
Lupus
Metabolic disorders
Metabolic syndrome
Mortality
Mortality patterns
Nutrients
Nutritional status
Obesity
Prevention
Review
Risk factors
Systemic lupus erythematosus
Vitamin E
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Summary:Systemic lupus erythematosus (SLE) is a chronic pathology characterized by a bimodal mortality pattern attributed to clinical disease activity and cardiovascular disease (CVD). A complex interaction between traditional CVD risk factors such as obesity, dyslipidemia, smoking, insulin resistance, metabolic syndrome, and hypertension, as well as the presence of non-traditional CVD risk factors such as hyperhomocysteinemia, pro-inflammatory cytokines, and C-reactive protein levels, has been suggested as a cause of the high prevalence of CVD in SLE patients. On the other hand, environmental factors, such as nutritional status, could influence the disease's prognosis; several nutrients have immunomodulators, antioxidants, and anti-cardiometabolic risk properties which could reduce SLE severity and organ damage by decreasing the development of traditional and non-traditional CVD risk factors. Therefore, this critical literature review discusses the therapeutic potential of nutritional approaches that could modulate the development of the main comorbidities related to CVD risk in SLE patients.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15041036