Prognostic Prediction Model for Glioblastoma: A Ferroptosis-Related Gene Prediction Model and Independent External Validation

Glioblastoma (GBM) is the most common primary malignant intracranial tumor with a poor prognosis. Ferroptosis is a newly discovered, iron-dependent, regulated cell death, and recent studies suggest its close correlation to GBM. The transcriptome and clinical data were obtained for patients diagnosed...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2023-02, Vol.12 (4), p.1341
Main Authors: Chen, Wenlin, Lei, Chuxiang, Wang, Yuekun, Guo, Dan, Zhang, Sumei, Wang, Xiaoxi, Zhang, Zixin, Wang, Yu, Ma, Wenbin
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
Brain cancer
Brain research
Cancer
Cancer therapies
Care and treatment
Cell death
Chemotherapy
Clinical medicine
DNA methylation
Ferroptosis
Gene expression
Genetic aspects
Genomes
Glioblastoma multiforme
Health aspects
Medical prognosis
Patient outcomes
Polymerase chain reaction
Prognosis
Regression analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glioblastoma (GBM) is the most common primary malignant intracranial tumor with a poor prognosis. Ferroptosis is a newly discovered, iron-dependent, regulated cell death, and recent studies suggest its close correlation to GBM. The transcriptome and clinical data were obtained for patients diagnosed with GBM from TCGA, GEO, and CGGA. Ferroptosis-related genes were identified, and a risk score model was constructed using Lasso regression analyses. Survival was evaluated by univariate or multivariate Cox regressions and Kaplan-Meier analyses, and further analyses were performed between the high- and low-risk groups. There were 45 ferroptosis-related different expressed genes between GBM and normal brain tissues. The prognostic risk score model was based on four favorable genes, and , and four unfavorable genes, , and . A significant difference in OS between high- and low-risk groups was observed in both the training cohort ( < 0.001) and the validation cohorts ( = 0.029 and 0.037). Enrichment analysis of pathways and immune cells and functioning was conducted between the two risk groups. A novel prognostic model for GBM patients was developed based on eight ferroptosis-related genes, suggesting a potential prediction effect of the risk score model in GBM.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12041341