Vitamin D and Diabetic Kidney Disease

Vitamin D is a hormone involved in many physiological processes. Its active form, 1,25(OH) D , modulates serum calcium-phosphate homeostasis and skeletal homeostasis. A growing body of evidence has demonstrated the renoprotective effects of vitamin D. Vitamin D modulates endothelial function, is ass...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-02, Vol.24 (4), p.3751
Main Authors: Huang, Ho-Yin, Lin, Ting-Wei, Hong, Zi-Xuan, Lim, Lee-Moay
Format: Article
Language:English
Subjects:
Aldosterone
Angiotensin
Calciferol
Calcitriol
Calcium (blood)
Calcium homeostasis
Calcium phosphates
Cardiovascular diseases
Chronic kidney failure
Diabetes
Diabetes mellitus
Diabetes Mellitus - metabolism
Diabetic Nephropathies - metabolism
Diabetic nephropathy
Diet therapy
End-stage renal disease
Enzymes
Gene expression
Glucose
Health aspects
Homeostasis
Humans
Hyperglycemia
Insulin resistance
Kidney - metabolism
Kidney diseases
Kidney Failure, Chronic - metabolism
Medical research
Medicine, Experimental
Metabolism
Paricalcitol
Pathogenesis
Phosphates
Proteins
Receptors, Calcitriol - metabolism
Renin
Renin-Angiotensin System
Review
Vitamin D
Vitamin D - metabolism
Vitamin D - pharmacology
Vitamin deficiency
Vitamins - pharmacology
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Summary:Vitamin D is a hormone involved in many physiological processes. Its active form, 1,25(OH) D , modulates serum calcium-phosphate homeostasis and skeletal homeostasis. A growing body of evidence has demonstrated the renoprotective effects of vitamin D. Vitamin D modulates endothelial function, is associated with podocyte preservation, regulates the renin-angiotensin-aldosterone system, and has anti-inflammatory effects. Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease worldwide. There are numerous studies supporting vitamin D as a renoprotector, potentially delaying the onset of DKD. This review summarizes the findings of current research on vitamin D and its role in DKD.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24043751