Geriatric Assessment Implementation before Chemotherapy in MEtastatic Prostate Cancer, Results from the Real-Life Study GAMERS

Geriatric assessment (GA) can predict and improve treatment tolerance and estimate overall survival in older patients with cancer. Several international organizations promote GA; however, data related to its implementation in daily clinical practice are still limited. We aimed to describe GA impleme...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-02, Vol.12 (4), p.1636
Main Authors: Gluszak, Cassandre, Campion, Loïc, Seegers, Valérie, Cojocarasu, Oana, Commer, Jean-Marie, Priou, Frank, Rolland, Frédéric, Terret, Catherine, Abadie-Lacourtoisie, Sophie
Format: Article
Language:English
Subjects:
Brief Report
Cancer
Care and treatment
Chemotherapy
Clinical medicine
Comorbidity
Geriatric assessment
Geriatrics
Metastasis
Methods
Oncology
Patients
Polypharmacy
Prostate cancer
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Summary:Geriatric assessment (GA) can predict and improve treatment tolerance and estimate overall survival in older patients with cancer. Several international organizations promote GA; however, data related to its implementation in daily clinical practice are still limited. We aimed to describe GA implementation in patients over 75 years old with metastatic prostate cancer treated with docetaxel as first-line treatment, and with positive G8 screening test or frailty criteria. This retrospective real-world study included 224 patients treated from 2014 to 2021 in four French centers, including 131 patients with a theoretical indication of GA. Among the latter, 51 (38.9%) patients had GA. The main barriers to GA were the lack of systematic screening (32/80, 40.0%), unavailability of geriatric physician (20/80, 25.0%), and absence of referral despite a positive screening test (12/80, 15.0%). With GA performed in only one-third of the patients with a theoretical indication in daily clinical practice, mostly due to an absence of screening test, the use of GA is currently sub-optimal.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12041636