Are Predictors for Overall Mortality in COPD Patients Robust over Time?

(1) Background: Mortality is a major outcome in research on chronic obstructive pulmonary disease (COPD) with various predictors described. However, the dynamic courses of important predictors over time are disregarded. This study evaluates if longitudinal assessment of predictors provides additiona...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-02, Vol.12 (4), p.1587
Main Authors: Sievi, Noriane A, Sepin, Jerome, Roeder, Maurice, Brack, Thomas, Brutsche, Martin H, Frey, Martin, Irani, Sarosh, Leuppi, Jörg D, Thurnheer, Robert, Clarenbach, Christian F, Kohler, Malcolm
Format: Article
Language:English
Subjects:
Airway management
Body mass index
Cardiovascular disease
Chronic obstructive pulmonary disease
Clinical medicine
Coronary vessels
Demographic aspects
Development and progression
Dyspnea
Family physicians
Gases
Hypertension
Longitudinal studies
Lung diseases
Lung diseases, Obstructive
Medical prognosis
Medical records
Mortality
Patient outcomes
Patients
Risk factors
Variables
Vein & artery diseases
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Summary:(1) Background: Mortality is a major outcome in research on chronic obstructive pulmonary disease (COPD) with various predictors described. However, the dynamic courses of important predictors over time are disregarded. This study evaluates if longitudinal assessment of predictors provides additional information on the mortality risk in COPD when compared with a cross-sectional analysis.; (2) In a longitudinal, prospective, non-interventional cohort study including mild to very severe COPD patients, mortality and its various possible predictors were annually assessed up to seven years.; (3) Results: 297 patients were analysed. Mean (SD) age was 62.5 (7.6) years and 66% males. Mean (SD) FEV1 was 48.8 (21.4)%. A total of 105 events (35.4%) happened with a median (95% CI) survival time of 8.2 (7.2/NA) years. No evidence for a difference between the raw variable and the variable history on the predictive value for all tested variables over each visit was found. There was no evidence for changing effect estimates (coefficients) across the study visits due to the longitudinal assessment; (4) Conclusions: We found no evidence that predictors of mortality in COPD are time dependent. This implies that cross-sectional measured predictors show robust effect estimates over time and multiple assessments seem not to change the predictive value of the measure.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12041587