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Blood Type A1 Mismatch Does Not Affect Heart Transplant Outcomes at One Year

There are subtypes within blood type A, termed non-A1, that have reduced expression of A antigen on cell surfaces. This can result in the development of anti-A1 antibodies. There is limited information regarding the impact of this in heart transplant (HTx) recipients. We conducted a single-center co...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-02, Vol.12 (4), p.1337
Main Authors: Cao, Louie, Kim, Seongkyu, Klapper, Ellen, Kobashigawa, Jon A, Kittleson, Michelle M
Format: Article
Language:English
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Summary:There are subtypes within blood type A, termed non-A1, that have reduced expression of A antigen on cell surfaces. This can result in the development of anti-A1 antibodies. There is limited information regarding the impact of this in heart transplant (HTx) recipients. We conducted a single-center cohort study of 142 Type A HTx recipients in which we compared outcomes of a match group (an A1/O heart into an A1 recipient or a non-A1/O heart into a non-A1 recipient) with a mismatch group (an A1 heart into a non-A1 recipient or a non-A1 heart into an A1 recipient). At one year post-transplant, there were no differences between the groups in survival, freedom from non-fatal major adverse cardiovascular events, freedom from any treated rejection, or freedom from cardiac allograft vasculopathy. There was an increased hospital length of stay in the mismatch group (13.5 vs. 17.1 days, = 0.04). Our study showed that A1 mismatch was not associated with worse outcomes at one year post-HTx.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12041337