Nanostructure Mediated Piezoelectric Effect of Tetragonal BaTiO3 Coatings on Bone Mesenchymal Stem Cell Shape and Osteogenic Differentiation

In recent years, porous titanium (Ti) scaffolds with BaTiO3 coatings have been designed to promote bone regeneration. However, the phase transitions of BaTiO3 have been understudied, and their coatings have yielded low effective piezoelectric coefficients (EPCs < 1 pm/V). In addition, piezoelectr...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-02, Vol.24 (4), p.4051
Main Authors: Zheng, Yafei, Zhao, Lingzhou, Li, Ying, Zhang, Xinyuan, Zhang, Wei, Wang, Jing, Liu, Lipeng, An, Weikang, Jiao, Hua, Ma, Chufan
Format: Article
Language:English
Subjects:
Barium titanates
Biocompatibility
Biological activity
Bone growth
Bone marrow
Cell differentiation
Cell proliferation
Cell size
Coating effects
Coatings
Differentiation (biology)
Electric fields
Elongation
Lamellipodia
Mechanical properties
Mesenchymal stem cells
Morphology
Nanomaterials
Nanoparticles
Nanotechnology
Osseointegration
Phase transitions
Pseudopodia
Regeneration
Regeneration (physiology)
Stem cells
Transplants & implants
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Summary:In recent years, porous titanium (Ti) scaffolds with BaTiO3 coatings have been designed to promote bone regeneration. However, the phase transitions of BaTiO3 have been understudied, and their coatings have yielded low effective piezoelectric coefficients (EPCs < 1 pm/V). In addition, piezoelectric nanomaterials bring many advantages in eliciting cell-specific responses. However, no study has attempted to design a nanostructured BaTiO3 coating with high EPCs. Herein, nanoparticulate tetragonal phase BaTiO3 coatings with cube-like nanoparticles but different effective piezoelectric coefficients were fabricated via anodization combining two hydrothermal processes. The effects of nanostructure-mediated piezoelectricity on the spreading, proliferation, and osteogenic differentiation of human jaw bone marrow mesenchymal stem cells (hJBMSCs) were explored. We found that the nanostructured tetragonal BaTiO3 coatings exhibited good biocompatibility and an EPC-dependent inhibitory effect on hJBMSC proliferation. The nanostructured tetragonal BaTiO3 coatings of relatively smaller EPCs (
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24044051