Corneal Optical Densitometry in the Evaluation of 2-Year Graft Function Following Endothelial Keratoplasty

This study aimed to assess clinical application of the Scheimpflug corneal tomography for objective evaluation of corneal optical density in eyes undergoing Descemet's stripping endothelial keratoplasty (DSEK). In this prospective study, 39 pseudophakic eyes with bullous keratopathy were enroll...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-02, Vol.12 (4), p.1552
Main Authors: Piotrowiak-Słupska, Ilona, Kałużny, Bartłomiej J, Malukiewicz, Grażyna
Format: Article
Language:English
Subjects:
Automation
Care and treatment
Cataracts
Clinical medicine
Cornea
Corneal diseases
Corneal transplantation
Densitometry
Diagnosis
Edema
Endothelium
Eye surgery
Health aspects
Ophthalmology
Patient outcomes
Standard deviation
Statistical significance
Tomography
Transplantation
Variance analysis
Visual acuity
Visual impairment
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Summary:This study aimed to assess clinical application of the Scheimpflug corneal tomography for objective evaluation of corneal optical density in eyes undergoing Descemet's stripping endothelial keratoplasty (DSEK). In this prospective study, 39 pseudophakic eyes with bullous keratopathy were enrolled. All eyes underwent primary DSEK. Ophthalmic examination included best corrected visual acuity (BCVA) measurement, biomicroscopy, Scheimpflug tomography, pachymetry, and endothelial cell count. All measurements were taken preoperatively and within a 2-year follow-up period. Gradual BCVA improvement was observed in all patients. After two years, the mean and median BCVA values were 0.18 logMAR. A decrease in central corneal thickness was noted only during the first 3 months postoperatively and was followed by a gradual increase. Corneal densitometry decreased constantly and most significantly in the first 3 months postoperatively. The consecutive decrease in endothelial cell count of the transplanted cornea was most significant during the first 6 months postoperatively. Six months postoperatively, the strongest correlation (Spearman's r = -0.41) with BCVA was found for densitometry. This tendency was maintained throughout the entire follow-up period. Corneal densitometry is applicable for objective monitoring of early and late outcomes of endothelial keratoplasty, showing a higher correlation with visual acuity than pachymetry and endothelial cell density.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12041552