Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the extracellular matrix and the basement membrane. Thus, these enzymes regulate airway remodeling, which is a major pathological feature of chronic obstructive pulmonary disease (COPD). Furthermore, proteolytic destru...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-02, Vol.24 (4), p.3786
Main Authors: Christopoulou, Maria-Elpida, Papakonstantinou, Eleni, Stolz, Daiana
Format: Article
Language:English
Subjects:
Arthritis
Binding sites
Chronic obstructive pulmonary disease
Clinical trials
Collagen
Elastin
Emphysema
Enzymes
Extracellular matrix
Extracellular Matrix - metabolism
Humans
Literature reviews
Lung - metabolism
Lung diseases
Lung diseases, Obstructive
Lungs
Matrix metalloproteinase
Matrix metalloproteinases
Matrix Metalloproteinases - metabolism
MicroRNAs
Obstructive lung disease
Peptides
Proteases
Proteins
Proteolysis
Proteolytic enzymes
Pulmonary Disease, Chronic Obstructive - metabolism
Pulmonary Emphysema - metabolism
Respiratory function
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the extracellular matrix and the basement membrane. Thus, these enzymes regulate airway remodeling, which is a major pathological feature of chronic obstructive pulmonary disease (COPD). Furthermore, proteolytic destruction in the lungs may lead to loss of elastin and the development of emphysema, which is associated with poor lung function in COPD patients. In this literature review, we describe and appraise evidence from the recent literature regarding the role of different MMPs in COPD, as well as how their activity is regulated by specific tissue inhibitors. Considering the importance of MMPs in COPD pathogenesis, we also discuss MMPs as potential targets for therapeutic intervention in COPD and present evidence from recent clinical trials in this regard.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24043786