A DR/NIR Hybrid Polymeric Tool for Functional Bio-Coatings: Theoretical Study, Cytotoxicity, and Antimicrobial Activity

Among modern biomaterials, hybrid tools containing an organic component and a metal cation are recognized as added value, and, for many advanced biomedical applications, synthetic polymers are used as thin protective/functional coatings for medical or prosthetic devices and implants. These materials...

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Bibliographic Details
Published in:Polymers 2023-02, Vol.15 (4), p.883
Main Authors: Diana, Rosita, Gentile, Francesco Silvio, Concilio, Simona, Petrella, Antonello, Belvedere, Raffaella, Schibeci, Martina, Arciello, Angela, Di Costanzo, Luigi, Panunzi, Barbara
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial agents
Bioassays
Biocompatibility
Biological products
Biomedical engineering
Biomedical materials
Biopolymers
Coatings
Ethanol
Implants, Artificial
Medical imaging
Methicillin
Near infrared radiation
Phase transitions
Polymers
Printed materials
Prostheses
Prosthesis
Protective coatings
Surgical implants
Tissues
Toxicity
Transplants & implants
Zinc
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Summary:Among modern biomaterials, hybrid tools containing an organic component and a metal cation are recognized as added value, and, for many advanced biomedical applications, synthetic polymers are used as thin protective/functional coatings for medical or prosthetic devices and implants. These materials require specific non-degradability, biocompatibility, antimicrobial, and antiproliferative properties to address safety aspects concerning their use in medicine. Moreover, bioimaging monitoring of the biomedical device and/or implant through biological tissues is a desirable ability. This article reports a novel hybrid metallopolymer obtained by grafting zinc-coordinated fragments to an organic polymeric matrix. This hybrid polymer, owing to its relevant emission in the deep red to near-infrared (DR/NIR) region, is monitorable; therefore, it represents a potential material for biomedical coating. Furthermore, it shows good biocompatibility and adhesion properties and excellent stability in slightly acidic/basic water solutions. Finally, in contact with the superficial layers of human skin, it shows antimicrobial properties against bacterial strains.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym15040883