Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles

Particulate matter, including iron nanoparticles, is one of the constituents of ambient air pollution. We assessed the effect of iron oxide (Fe2O3) nanoparticles on the structure and function of the brain of rats. Electron microscopy showed Fe2O3 nanoparticles in the tissues of olfactory bulbs but n...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-02, Vol.24 (4), p.3572
Main Authors: Minigalieva, Ilzira A., Ryabova, Yuliya V., Shelomencev, Ivan G., Amromin, Lev A., Minigalieva, Regina F., Sutunkova, Yuliya M., Privalova, Larisa I., Sutunkova, Marina P.
Format: Article
Language:English
Subjects:
Air pollution
Animals
Axons
Basal ganglia
Behavior
Brain
Central nervous system
Electron microscopy
Ferric oxide
Intranasal administration
Iron constituents
Iron oxides
Microscopy
Mitochondria
Myelin
Nanoparticles
Olfactory bulb
Oxidative stress
Particulate matter
Sheaths
Structure-function relationships
Toxicity
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Summary:Particulate matter, including iron nanoparticles, is one of the constituents of ambient air pollution. We assessed the effect of iron oxide (Fe2O3) nanoparticles on the structure and function of the brain of rats. Electron microscopy showed Fe2O3 nanoparticles in the tissues of olfactory bulbs but not in the basal ganglia of the brain after their subchronic intranasal administration. We observed an increase in the number of axons with damaged myelin sheaths and in the proportion of pathologically altered mitochondria in the brains of the exposed animals against the background of almost stable blood parameters. We conclude that the central nervous system can be a target for toxicity of low-dose exposure to Fe2O3 nanoparticles.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24043572