Loading…
Association of Sonographic Sarcopenia and Falls in Older Adults Presenting to the Emergency Department
To determine the association between point-of-care-ultrasonography (POCUS)-measured sarcopenia and grip strength, as well as the history of prior-year falls among older adults admitted to the emergency department observation unit (EDOU). This cross-sectional observational study was conducted over 8...
Saved in:
Published in: | Journal of clinical medicine 2023-02, Vol.12 (4), p.1251 |
---|---|
Main Authors: | , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | cdi_FETCH-LOGICAL-c434t-53bb47e1b4b1557e9b4e56dc5ce1bae2056224cc3c37b156a17464132919af5b3 |
container_end_page | |
container_issue | 4 |
container_start_page | 1251 |
container_title | Journal of clinical medicine |
container_volume | 12 |
creator | Wongtangman, Thiti Thatphet, Phraewa Shokoohi, Hamid McFadden, Kathleen Ma, Irene Al Saud, Ahad Vivian, Rachel Hines, Ryan Gullikson, Jamie Morone, Christina Parente, Jason Perkisas, Stany Liu, Shan W |
description | To determine the association between point-of-care-ultrasonography (POCUS)-measured sarcopenia and grip strength, as well as the history of prior-year falls among older adults admitted to the emergency department observation unit (EDOU).
This cross-sectional observational study was conducted over 8 months at a large urban teaching hospital. A consecutive sample of patients who were 65 years or older and admitted to the EDOU were enrolled in the study. Using standardized techniques, trained research assistants and co-investigators measured patients' biceps brachii and thigh quadriceps muscles via a linear transducer. Grip strength was measured using a Jamar Hydraulic Hand Dynamometer. Participants were surveyed regarding their history of falls in the prior year. Logistic regression analyses assessed the relationship of sarcopenia and grip strength to a history of falls (the primary outcome).
Among 199 participants (55% female), 46% reported falling in the prior year. The median biceps thickness was 2.22 cm with an Interquartile range [IQR] of 1.87-2.74, and the median thigh muscle thickness was 2.91 cm with an IQR of 2.40-3.49. A univariate logistic regression analysis demonstrated a correlation between higher thigh muscle thickness, normal grip strength, and history of prior-year falling, with an odds ratio [OR] of 0.67 (95% conference interval [95%CI] 0.47-0.95) and an OR of 0.51 (95%CI 0.29-0.91), respectively. In multivariate logistic regression, only higher thigh muscle thickness was correlated with a history of prior-year falls, with an OR of 0.59 (95% CI 0.38-0.91).
POCUS-measured thigh muscle thickness has the potential to identify patients who have fallen and thus are at high risk for future falls. |
doi_str_mv | 10.3390/jcm12041251 |
format | article |
fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9968231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A750335002</galeid><sourcerecordid>A750335002</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-53bb47e1b4b1557e9b4e56dc5ce1bae2056224cc3c37b156a17464132919af5b3</originalsourceid><addsrcrecordid>eNptkk1r3DAQhkVoSUKaU-5B0EuhbKpPy74UljRpC4EU0p6FLI-9WmTJlexC_n21TbpsSqWDhpln3mHEi9AFJVecN-TD1o6UEUGZpEfolBGlVoTX_NVBfILOc96ScupaMKqO0Qmvai5VrU5Rv845WmdmFwOOPX6IIQ7JTBtn8YNJNk4QnMEmdPjWeJ-xC_jed5Dwulv8nPG3BBnC7MKA54jnDeCbEdIAwT7iTzCZNI-l_Aa97o3PcP78nqEftzffr7-s7u4_f71e362s4GJeSd62QgFtRUulVNC0AmTVWWlLzgAjsmJMWMstV4WoDFWiEpSzhjamly0_Qx-fdKelHaGzZXQyXk_JjSY96micflkJbqOH-Es3TVUzTovAu2eBFH8ukGc9umzBexMgLlkzVROiavEHffsPuo1LCmW9QqlGymonuacG40G70Mcy1-5E9VpJwrkkZEdd_Ycqt4PR2RigdyX_ouH9U4NNMecE_X5HSvTOGfrAGYW-PPyWPfvXB_w3l0SyjA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2779556682</pqid></control><display><type>article</type><title>Association of Sonographic Sarcopenia and Falls in Older Adults Presenting to the Emergency Department</title><source>Publicly Available Content Database</source><source>PubMed Central</source><source>Coronavirus Research Database</source><creator>Wongtangman, Thiti ; Thatphet, Phraewa ; Shokoohi, Hamid ; McFadden, Kathleen ; Ma, Irene ; Al Saud, Ahad ; Vivian, Rachel ; Hines, Ryan ; Gullikson, Jamie ; Morone, Christina ; Parente, Jason ; Perkisas, Stany ; Liu, Shan W</creator><creatorcontrib>Wongtangman, Thiti ; Thatphet, Phraewa ; Shokoohi, Hamid ; McFadden, Kathleen ; Ma, Irene ; Al Saud, Ahad ; Vivian, Rachel ; Hines, Ryan ; Gullikson, Jamie ; Morone, Christina ; Parente, Jason ; Perkisas, Stany ; Liu, Shan W</creatorcontrib><description>To determine the association between point-of-care-ultrasonography (POCUS)-measured sarcopenia and grip strength, as well as the history of prior-year falls among older adults admitted to the emergency department observation unit (EDOU).
This cross-sectional observational study was conducted over 8 months at a large urban teaching hospital. A consecutive sample of patients who were 65 years or older and admitted to the EDOU were enrolled in the study. Using standardized techniques, trained research assistants and co-investigators measured patients' biceps brachii and thigh quadriceps muscles via a linear transducer. Grip strength was measured using a Jamar Hydraulic Hand Dynamometer. Participants were surveyed regarding their history of falls in the prior year. Logistic regression analyses assessed the relationship of sarcopenia and grip strength to a history of falls (the primary outcome).
Among 199 participants (55% female), 46% reported falling in the prior year. The median biceps thickness was 2.22 cm with an Interquartile range [IQR] of 1.87-2.74, and the median thigh muscle thickness was 2.91 cm with an IQR of 2.40-3.49. A univariate logistic regression analysis demonstrated a correlation between higher thigh muscle thickness, normal grip strength, and history of prior-year falling, with an odds ratio [OR] of 0.67 (95% conference interval [95%CI] 0.47-0.95) and an OR of 0.51 (95%CI 0.29-0.91), respectively. In multivariate logistic regression, only higher thigh muscle thickness was correlated with a history of prior-year falls, with an OR of 0.59 (95% CI 0.38-0.91).
POCUS-measured thigh muscle thickness has the potential to identify patients who have fallen and thus are at high risk for future falls.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12041251</identifier><identifier>PMID: 36835787</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aged patients ; Clinical medicine ; Consent ; Diagnosis ; Diagnosis, Ultrasonic ; Emergency medical care ; Falls ; Falls (Accidents) ; Geriatrics ; Grip strength ; Health aspects ; Hospital costs ; Infections ; Measurement ; Medical examination ; Mortality ; Muscle strength ; Older people ; Point of care testing ; Polypharmacy ; Risk factors ; Sarcopenia ; Severe acute respiratory syndrome coronavirus 2 ; Ultrasonic imaging</subject><ispartof>Journal of clinical medicine, 2023-02, Vol.12 (4), p.1251</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c434t-53bb47e1b4b1557e9b4e56dc5ce1bae2056224cc3c37b156a17464132919af5b3</cites><orcidid>0000-0003-2127-1339 ; 0000-0002-1280-3594 ; 0000-0003-1800-4280 ; 0000-0002-4192-327X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2779556682/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2779556682?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,38516,43895,44590,53791,53793,74412,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36835787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wongtangman, Thiti</creatorcontrib><creatorcontrib>Thatphet, Phraewa</creatorcontrib><creatorcontrib>Shokoohi, Hamid</creatorcontrib><creatorcontrib>McFadden, Kathleen</creatorcontrib><creatorcontrib>Ma, Irene</creatorcontrib><creatorcontrib>Al Saud, Ahad</creatorcontrib><creatorcontrib>Vivian, Rachel</creatorcontrib><creatorcontrib>Hines, Ryan</creatorcontrib><creatorcontrib>Gullikson, Jamie</creatorcontrib><creatorcontrib>Morone, Christina</creatorcontrib><creatorcontrib>Parente, Jason</creatorcontrib><creatorcontrib>Perkisas, Stany</creatorcontrib><creatorcontrib>Liu, Shan W</creatorcontrib><title>Association of Sonographic Sarcopenia and Falls in Older Adults Presenting to the Emergency Department</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>To determine the association between point-of-care-ultrasonography (POCUS)-measured sarcopenia and grip strength, as well as the history of prior-year falls among older adults admitted to the emergency department observation unit (EDOU).
This cross-sectional observational study was conducted over 8 months at a large urban teaching hospital. A consecutive sample of patients who were 65 years or older and admitted to the EDOU were enrolled in the study. Using standardized techniques, trained research assistants and co-investigators measured patients' biceps brachii and thigh quadriceps muscles via a linear transducer. Grip strength was measured using a Jamar Hydraulic Hand Dynamometer. Participants were surveyed regarding their history of falls in the prior year. Logistic regression analyses assessed the relationship of sarcopenia and grip strength to a history of falls (the primary outcome).
Among 199 participants (55% female), 46% reported falling in the prior year. The median biceps thickness was 2.22 cm with an Interquartile range [IQR] of 1.87-2.74, and the median thigh muscle thickness was 2.91 cm with an IQR of 2.40-3.49. A univariate logistic regression analysis demonstrated a correlation between higher thigh muscle thickness, normal grip strength, and history of prior-year falling, with an odds ratio [OR] of 0.67 (95% conference interval [95%CI] 0.47-0.95) and an OR of 0.51 (95%CI 0.29-0.91), respectively. In multivariate logistic regression, only higher thigh muscle thickness was correlated with a history of prior-year falls, with an OR of 0.59 (95% CI 0.38-0.91).
POCUS-measured thigh muscle thickness has the potential to identify patients who have fallen and thus are at high risk for future falls.</description><subject>Aged patients</subject><subject>Clinical medicine</subject><subject>Consent</subject><subject>Diagnosis</subject><subject>Diagnosis, Ultrasonic</subject><subject>Emergency medical care</subject><subject>Falls</subject><subject>Falls (Accidents)</subject><subject>Geriatrics</subject><subject>Grip strength</subject><subject>Health aspects</subject><subject>Hospital costs</subject><subject>Infections</subject><subject>Measurement</subject><subject>Medical examination</subject><subject>Mortality</subject><subject>Muscle strength</subject><subject>Older people</subject><subject>Point of care testing</subject><subject>Polypharmacy</subject><subject>Risk factors</subject><subject>Sarcopenia</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Ultrasonic imaging</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><recordid>eNptkk1r3DAQhkVoSUKaU-5B0EuhbKpPy74UljRpC4EU0p6FLI-9WmTJlexC_n21TbpsSqWDhpln3mHEi9AFJVecN-TD1o6UEUGZpEfolBGlVoTX_NVBfILOc96ScupaMKqO0Qmvai5VrU5Rv845WmdmFwOOPX6IIQ7JTBtn8YNJNk4QnMEmdPjWeJ-xC_jed5Dwulv8nPG3BBnC7MKA54jnDeCbEdIAwT7iTzCZNI-l_Aa97o3PcP78nqEftzffr7-s7u4_f71e362s4GJeSd62QgFtRUulVNC0AmTVWWlLzgAjsmJMWMstV4WoDFWiEpSzhjamly0_Qx-fdKelHaGzZXQyXk_JjSY96micflkJbqOH-Es3TVUzTovAu2eBFH8ukGc9umzBexMgLlkzVROiavEHffsPuo1LCmW9QqlGymonuacG40G70Mcy1-5E9VpJwrkkZEdd_Ycqt4PR2RigdyX_ouH9U4NNMecE_X5HSvTOGfrAGYW-PPyWPfvXB_w3l0SyjA</recordid><startdate>20230204</startdate><enddate>20230204</enddate><creator>Wongtangman, Thiti</creator><creator>Thatphet, Phraewa</creator><creator>Shokoohi, Hamid</creator><creator>McFadden, Kathleen</creator><creator>Ma, Irene</creator><creator>Al Saud, Ahad</creator><creator>Vivian, Rachel</creator><creator>Hines, Ryan</creator><creator>Gullikson, Jamie</creator><creator>Morone, Christina</creator><creator>Parente, Jason</creator><creator>Perkisas, Stany</creator><creator>Liu, Shan W</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2127-1339</orcidid><orcidid>https://orcid.org/0000-0002-1280-3594</orcidid><orcidid>https://orcid.org/0000-0003-1800-4280</orcidid><orcidid>https://orcid.org/0000-0002-4192-327X</orcidid></search><sort><creationdate>20230204</creationdate><title>Association of Sonographic Sarcopenia and Falls in Older Adults Presenting to the Emergency Department</title><author>Wongtangman, Thiti ; Thatphet, Phraewa ; Shokoohi, Hamid ; McFadden, Kathleen ; Ma, Irene ; Al Saud, Ahad ; Vivian, Rachel ; Hines, Ryan ; Gullikson, Jamie ; Morone, Christina ; Parente, Jason ; Perkisas, Stany ; Liu, Shan W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-53bb47e1b4b1557e9b4e56dc5ce1bae2056224cc3c37b156a17464132919af5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged patients</topic><topic>Clinical medicine</topic><topic>Consent</topic><topic>Diagnosis</topic><topic>Diagnosis, Ultrasonic</topic><topic>Emergency medical care</topic><topic>Falls</topic><topic>Falls (Accidents)</topic><topic>Geriatrics</topic><topic>Grip strength</topic><topic>Health aspects</topic><topic>Hospital costs</topic><topic>Infections</topic><topic>Measurement</topic><topic>Medical examination</topic><topic>Mortality</topic><topic>Muscle strength</topic><topic>Older people</topic><topic>Point of care testing</topic><topic>Polypharmacy</topic><topic>Risk factors</topic><topic>Sarcopenia</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wongtangman, Thiti</creatorcontrib><creatorcontrib>Thatphet, Phraewa</creatorcontrib><creatorcontrib>Shokoohi, Hamid</creatorcontrib><creatorcontrib>McFadden, Kathleen</creatorcontrib><creatorcontrib>Ma, Irene</creatorcontrib><creatorcontrib>Al Saud, Ahad</creatorcontrib><creatorcontrib>Vivian, Rachel</creatorcontrib><creatorcontrib>Hines, Ryan</creatorcontrib><creatorcontrib>Gullikson, Jamie</creatorcontrib><creatorcontrib>Morone, Christina</creatorcontrib><creatorcontrib>Parente, Jason</creatorcontrib><creatorcontrib>Perkisas, Stany</creatorcontrib><creatorcontrib>Liu, Shan W</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wongtangman, Thiti</au><au>Thatphet, Phraewa</au><au>Shokoohi, Hamid</au><au>McFadden, Kathleen</au><au>Ma, Irene</au><au>Al Saud, Ahad</au><au>Vivian, Rachel</au><au>Hines, Ryan</au><au>Gullikson, Jamie</au><au>Morone, Christina</au><au>Parente, Jason</au><au>Perkisas, Stany</au><au>Liu, Shan W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Sonographic Sarcopenia and Falls in Older Adults Presenting to the Emergency Department</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2023-02-04</date><risdate>2023</risdate><volume>12</volume><issue>4</issue><spage>1251</spage><pages>1251-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>To determine the association between point-of-care-ultrasonography (POCUS)-measured sarcopenia and grip strength, as well as the history of prior-year falls among older adults admitted to the emergency department observation unit (EDOU).
This cross-sectional observational study was conducted over 8 months at a large urban teaching hospital. A consecutive sample of patients who were 65 years or older and admitted to the EDOU were enrolled in the study. Using standardized techniques, trained research assistants and co-investigators measured patients' biceps brachii and thigh quadriceps muscles via a linear transducer. Grip strength was measured using a Jamar Hydraulic Hand Dynamometer. Participants were surveyed regarding their history of falls in the prior year. Logistic regression analyses assessed the relationship of sarcopenia and grip strength to a history of falls (the primary outcome).
Among 199 participants (55% female), 46% reported falling in the prior year. The median biceps thickness was 2.22 cm with an Interquartile range [IQR] of 1.87-2.74, and the median thigh muscle thickness was 2.91 cm with an IQR of 2.40-3.49. A univariate logistic regression analysis demonstrated a correlation between higher thigh muscle thickness, normal grip strength, and history of prior-year falling, with an odds ratio [OR] of 0.67 (95% conference interval [95%CI] 0.47-0.95) and an OR of 0.51 (95%CI 0.29-0.91), respectively. In multivariate logistic regression, only higher thigh muscle thickness was correlated with a history of prior-year falls, with an OR of 0.59 (95% CI 0.38-0.91).
POCUS-measured thigh muscle thickness has the potential to identify patients who have fallen and thus are at high risk for future falls.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36835787</pmid><doi>10.3390/jcm12041251</doi><orcidid>https://orcid.org/0000-0003-2127-1339</orcidid><orcidid>https://orcid.org/0000-0002-1280-3594</orcidid><orcidid>https://orcid.org/0000-0003-1800-4280</orcidid><orcidid>https://orcid.org/0000-0002-4192-327X</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2077-0383 |
ispartof | Journal of clinical medicine, 2023-02, Vol.12 (4), p.1251 |
issn | 2077-0383 2077-0383 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9968231 |
source | Publicly Available Content Database; PubMed Central; Coronavirus Research Database |
subjects | Aged patients Clinical medicine Consent Diagnosis Diagnosis, Ultrasonic Emergency medical care Falls Falls (Accidents) Geriatrics Grip strength Health aspects Hospital costs Infections Measurement Medical examination Mortality Muscle strength Older people Point of care testing Polypharmacy Risk factors Sarcopenia Severe acute respiratory syndrome coronavirus 2 Ultrasonic imaging |
title | Association of Sonographic Sarcopenia and Falls in Older Adults Presenting to the Emergency Department |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T19%3A08%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20Sonographic%20Sarcopenia%20and%20Falls%20in%20Older%20Adults%20Presenting%20to%20the%20Emergency%20Department&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Wongtangman,%20Thiti&rft.date=2023-02-04&rft.volume=12&rft.issue=4&rft.spage=1251&rft.pages=1251-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm12041251&rft_dat=%3Cgale_pubme%3EA750335002%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c434t-53bb47e1b4b1557e9b4e56dc5ce1bae2056224cc3c37b156a17464132919af5b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2779556682&rft_id=info:pmid/36835787&rft_galeid=A750335002&rfr_iscdi=true |