Family health conditions and parental occupational status modify the relationship between pediatric-onset multiple sclerosis and parental health-related quality of life

Background: The health-related quality of life (HRQoL) of children with multiple sclerosis (MS) is mediated by the HRQoL of their parents. Understanding factors that modify the relationship between the child’s MS diagnosis and parental HRQoL would inform interventions to improve the HRQoL of both pa...

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Bibliographic Details
Published in:Multiple sclerosis 2023-03, Vol.29 (3), p.447-456
Main Authors: O’Mahony, Julia, Banwell, Brenda, Laporte, Audrey, Brown, Adalsteinn, Bolongaita, Lady, Bar-Or, Amit, Yeh, E Ann, Marrie, Ruth Ann
Format: Article
Language:English
Subjects:
Canada
Child
Children
Demyelination
Diagnosis
Employment
Families & family life
Family Health
Humans
Multiple Sclerosis
Original Research Papers
Parents
Parents & parenting
Pediatrics
Prospective Studies
Quality of Life
Surveys and Questionnaires
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Summary:Background: The health-related quality of life (HRQoL) of children with multiple sclerosis (MS) is mediated by the HRQoL of their parents. Understanding factors that modify the relationship between the child’s MS diagnosis and parental HRQoL would inform interventions to improve the HRQoL of both parents and children living with MS. Objective: We evaluated whether the association between an MS diagnosis during childhood and parental HRQoL is modified by the presence of a family health condition or low socioeconomic position (SEP). Methods: Parents of children with MS or the transient illness, monophasic-acquired demyelinating syndromes (monoADS), were enrolled in a prospective Canadian study. Multivariable models evaluated whether the association between a child’s MS diagnosis (vs. monoADS) and parental HRQoL was modified by ⩾1 family health conditions or low SEP. Results: Two hundred seven parents and their children with MS (n = 65) or monoADS (n = 142) were included. We found a synergistic effect of an MS diagnosis and a family health condition on parental HRQoL. We also found a synergistic effect of having MS and a low SEP on parental HRQoL. Conclusion: Parents of children with MS who have another family health condition or a low SEP are at particularly high risk for low HRQoL.
ISSN:1352-4585
1477-0970
DOI:10.1177/13524585221144413