The Association of Human Leukocyte Antigens Complex with Type 1 Diabetes in the Omani Population

• Published in: Sultan Qaboos University medical journal 2023-02, Vol.23 (1), p.68-75
• Main Authors: Al-Balushi, Mohammed, Al-Badi, Samiya, Al-Yaarubi, Saif, Al-Riyami, Hamad, Al-Shidhani, Azza, Al-Hinai, Shaima, Alshirawi, Ali, Hasson, Sidgi, Said, Elias, Al-Jabri, Ali, Al Ansari, Aliya
• Format: Article
• Language: English
• Subjects: Ambulatory Care Facilities; Case-Control Studies; Child; Child, Preschool; Clinical & Basic Research; Diabetes Mellitus, Type 1 - genetics; HLA-DRB1 Chains - genetics; Hospitals, University; Humans
• ISSN: 2075-0528; 2075-051X; 2075-0528
• DOI: 10.18295/squmj.2.2022.016

Identification of the high risk alleles, genotypes and haplotypes of the human leukocyte antigens (HLA) in different populations is beneficial for understanding their roles in type 1 diabetes (T1D) pathogenesis and intervention practices. This study aimed to identify T1D-associated HLA gene alleles in the Omani population. The present case-control study included 73 diabetic seropositive children (mean age 9.08 ± 3.27 years) attending the paediatric clinic at Sultan Qaboos University Hospital in Muscat, Oman, and 110 healthy controls. , , , and genes were genotyped using a sequence-specific primer polymerase chain reaction (SSP-PCR). Two HLA class I alleles ( , ) and three class II alleles ( , and ) were associated with T1D susceptibility, while one class I ( ) and three class II ( , and ) alleles were associated with T1D protection. and alleles showed the strongest risk association among all alleles. Six residues (E , S , S , Y , V and K ) were significantly associated with T1D susceptibility. Heterozygous genotypes, / and / were significantly associated with T1D susceptibility (