Novel Gene Signatures Promote Epithelial-Mesenchymal Transition (EMT) in Glucose Deprivation-Based Microenvironment to Predict Recurrence‐Free Survival in Hepatocellular Carcinoma

Background. Current research studies have suggested that glucose deprivation (GD)-based tumor microenvironment (TME) can promote epithelial-mesenchymal transition (EMT) of tumor cells, leading to tumor invasion and metastasis. However, no one has yet studied detailedly the synthetic studies that inc...

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Published in:Journal of oncology 2023, Vol.2023, p.6114976-21
Main Authors: Huang, Yuan, Li, Shi-Rong, Gao, Ying-Jie, Zhu, Yan-hua, Zhang, Xiao-feng
Format: Article
Language:English
Subjects:
Cancer therapies
Cluster analysis
Datasets
Dextrose
Gene expression
Genes
Glucose
Hypoxia
Liver
Liver cancer
Medical diagnosis
Medical prognosis
Metastasis
Nomograms
Patients
Regression analysis
Stem cells
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Summary:Background. Current research studies have suggested that glucose deprivation (GD)-based tumor microenvironment (TME) can promote epithelial-mesenchymal transition (EMT) of tumor cells, leading to tumor invasion and metastasis. However, no one has yet studied detailedly the synthetic studies that include GD features in TME with EMT status. In our research, we comprehensively developed and validated a robust signature regarding GD and EMT status to provide prognostic value for patients with liver cancer. Methods. GD and EMT status were estimated with transcriptomic profiles based on WGCNA and t-SNE algorithms. Two cohorts of training (TCGA_LIHC) and validation (GSE76427) datasets were analyzed with the Cox regression and logistic regression analyses. We identified a 2-mRNA signature to establish a GD-EMT-based gene risk model for the prediction of HCC relapse. Results. Patients with significant GD-EMT status were divided into two subgroups: GDlow/EMTlow and GDhigh/EMThigh, with the latter having significantly worse recurrence-free survival (P
ISSN:1687-8450
1687-8450
1687-8469
DOI:10.1155/2023/6114976