Cross-Calibration of iDXA and pQCT Scanners at Rural and Urban Research Sites in The Gambia, West Africa

Between-scanner differences in measures of bone and body composition can obscure or exaggerate physiological differences in multi-site studies or the magnitude of changes in longitudinal studies. We conducted a cross-calibration study at two bone imaging centres in The Gambia, West Africa where DXA...

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Bibliographic Details
Published in:Calcified tissue international 2023-05, Vol.112 (5), p.573-583
Main Authors: Ó Breasail, Mícheál, Janha, Ramatoulie, Zengin, Ayse, Pearse, Camille, Jarjou, Landing, Prentice, Ann, Ward, Kate A.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon - methods
Adult
Africa, Western
Aged
Biochemistry
Biomedical and Life Sciences
Body composition
Body mass index
Bone composition
Bone Density - physiology
Bone imaging
Calibration
Cell Biology
Computed tomography
Dual energy X-ray absorptiometry
Endocrinology
Female
Gambia
Humans
Life Sciences
Lumbar Vertebrae
Male
Original Research
Orthopedics
Population studies
Scanners
Spine (lumbar)
Tibia
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Summary:Between-scanner differences in measures of bone and body composition can obscure or exaggerate physiological differences in multi-site studies or the magnitude of changes in longitudinal studies. We conducted a cross-calibration study at two bone imaging centres in The Gambia, West Africa where DXA (dual-energy X-ray absorptiometry) and pQCT (peripheral Quantitative-Computed Tomography) are routinely used. Repeat scans were obtained from 64 Gambian adults (58% Male) aged Mean(SD) 30.9 (13.5) years with Mean(SD) body mass index (BMI) 21.7 (4.0) kg/m 2 , using DXA (GE Lunar iDXA, whole body [WB], total hip [TH], lumbar spine [LS]) and pQCT (Stratec XCT2000L/XCT2000, tibia 4%, 50% sites). Between-scanner differences were tested using paired t tests ( p  
ISSN:1432-0827
0171-967X
1432-0827
DOI:10.1007/s00223-023-01071-6