Clinical Characteristics and Follow-up of Cases of Streptococcus suis Meningitis in Patients of Liuzhou, China

We analyzed the clinical characteristics and outcomes of patients with Streptococcus suis meningitis in Liuzhou, China, to improve diagnostic accuracy and lower the chances of misdiagnosis. The major clinical manifestations, auxiliary examination results, treatment strategies, treatment efficacy, an...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2023-03, Vol.108 (3), p.477-481
Main Authors: Deng, Shan, Lin, Baoquan, Weng, Baohui, Yang, Hong, Zhou, Kejian, Wu, Liya, Qin, Lu, Pan, Liya
Format: Article
Language:English
Subjects:
Activities of Daily Living
China
Follow-Up Studies
Hearing loss
Hearing Loss, Sensorineural
Humans
Meningitis
Meningitis, Bacterial
Streptococcal Infections - diagnosis
Streptococcus infections
Streptococcus suis
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Summary:We analyzed the clinical characteristics and outcomes of patients with Streptococcus suis meningitis in Liuzhou, China, to improve diagnostic accuracy and lower the chances of misdiagnosis. The major clinical manifestations, auxiliary examination results, treatment strategies, treatment efficacy, and follow-up results of 17 consecutively admitted patients with S. suis meningitis were evaluated. The most common clinical manifestations were fever (15/17), sensorineural hearing loss (13/17), headache (11/17), and altered mental status (8/17). In addition, 64.71% of the patients had residual symptoms of sensorineural hearing loss at discharge, and moderate disabilities occurred in 68.75% of the patients in the form of sensorineural deafness (11/17) and hemiparesis (1/17). The cerebrospinal fluid (CSF) of nine patients was used for metagenomic analysis with next-generation sequencing. The metagenomic analysis of CSF of four patients was positive, whereas blood and CSF cultures were negative. The average modified Rankin Scale (mRS) and Activities of Daily Living (ADL) scores improved significantly at the 6-month follow-up compared with those at admission (P < 0.05). There was no correlation between altered mRS and ADL scores and the CSF findings (P > 0.05). Early administration of antibiotics can prevent sensorineural hearing loss. Early CSF metagenomic analysis may be superior to blood and CSF culture.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.22-0515