Breast cancer relapses considering molecular biological characteristics

We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual f...

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Bibliographic Details
Published in:Journal of medicine and life 2023-01, Vol.16 (1), p.70-75
Main Authors: Smolanka, Ivan Ivanovich, Movchan, Oleksii Volodimirovich, Bagmut, Irina Yuriivna, Sheremet, Michael Ivanovich, Kolisnyk, Igor Leonidovich, Dosenko, Irina Viktorivna, Lyashcnko, Andriy Oleksandrovich, Ivankova, Oksana Mykolaivna, Loboda, Anton Dmitrovich, Shidlovskyi, Oleksandr Viktorovich
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms
Cancer therapies
Cloning
Endocrine therapy
ErbB-2 protein
Estrogens
Female
Genomes
Histology
Humans
Lymphatic system
Mastectomy
Menstruation
Metastasis
Mutation
Neoplasm Recurrence, Local
Original
Steroids
Tumors
Womens health
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Summary:We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual function, disease stage, histology form and grade, and molecular-biological subtype. The 5-year relapse-free rate for Group 1 was longer for Lum A and TN subtypes (60% and 40%, respectively) but shorter for Lum B and HER-2/neu-amplified subtypes (38% and 31%, respectively). Disease stage, tumor histology, and grade did not significantly affect relapse frequency in these patients. Relapses were more common in premenopausal patients and the Lum B subtype.
ISSN:1844-122X
1844-3117
DOI:10.25122/jml-2022-0189