CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia

Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessing this issue. This study ai...

Full description

Saved in:
Bibliographic Details
Published in:Kidney medicine 2023-03, Vol.5 (3), p.100593-100593, Article 100593
Main Authors: Maki, Kenji, Ohara, Tomoyuki, Hata, Jun, Shibata, Mao, Hirabayashi, Naoki, Honda, Takanori, Sakata, Satoko, Furuta, Yoshihiko, Akiyama, Masato, Yamasaki, Keisuke, Tatewaki, Yasuko, Taki, Yasuyuki, Kitazono, Takanari, Mikami, Tatsuya, Maeda, Tetsuya, Ono, Kenjiro, Mimura, Masaru, Nakashima, Kenji, Iga, Jun-ichi, Takebayashi, Minoru, Ninomiya, Toshiharu, Nakaji, Shigeyuki, Murashita, Koichi, Jung, Songee, Misawa, Mina, Ishizuka, Naoki, Akasaka, Hiroshi, Terayama, Yasuo, Yonezawa, Hisashi, Takahashi, Junko, Noguchi-Shinohara, Moeko, Komatsu, Junji, Shibata, Shutaro, Yuki-Nozaki, Sohshi, Bun, Shogyoku, Niimura, Hidehito, Shikimoto, Ryo, Kida, Hisashi, Fukada, Yasuyo, Kowa, Hisanori, Nakano, Toshiya, Wada, Kenji, Kishi, Masafumi, Ozaki, Tomoki, Tachibana, Ayumi, Yoshino, Yuta, Shu-ichi Ueno, Jun-ichi Iga, Ishikawa, Tomohisa, Yuki, Seiji, Koyama, Asuka, Kajitani, Naoto, Hashimoto, Mamoru, Ikeda, Manabu, Kokubo, Yoshihiro, Uchida, Kazuhiro, Esaki, Midori, Thyreau, Benjamin, Yonemoto, Koji, Yoshida, Hisako, Muto, Kaori, Inoue, Yusuke, Ri, Izen, Momozawa, Yukihide, Terao, Chikashi, Kubo, Michiaki, Kiyohara, Yutaka
Format: Article
Language:English
Subjects:
Albuminuria
brain atrophy
cognitive impairment
general population
magnetic resonance imaging
Original Research
white matter lesion
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessing this issue. This study aimed to examine the associations between the urinary albumin-creatinine ratio (UACR) and eGFR levels and brain atrophy and WMLV in a large-scale community-dwelling older population of Japanese. Population-based cross-sectional study. A total of 8,630 dementia-free community-dwelling Japanese aged greater than or equal to 65 years underwent brain magnetic resonance imaging scanning and screening examination of health status in 2016-2018. UACR and eGFR levels. The total brain volume (TBV)-to-intracranial volume (ICV) ratio (TBV/ICV), the regional brain volume-to-TBV ratio, and the WMLV-to-ICV ratio (WMLV/ICV). The associations of UACR and eGFR levels with the TBV/ICV, the regional brain volume-to-TBV ratio, and the WMLV/ICV were assessed by using an analysis of covariance. Higher UACR levels were significantly associated with lower TBV/ICV and higher geometric mean values of the WMLV/ICV (P for trend = 0.009 and
ISSN:2590-0595
2590-0595
DOI:10.1016/j.xkme.2022.100593