Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography

Radionuclide ventriculography (RNVG) can be used to quantify mechanical dyssynchrony and may be a valuable adjunct in the assessment of heart failure with reduced ejection fraction (HFrEF). The study aims to investigate the effect of beta-blockers on mechanical dyssynchrony using novel RNVG phase pa...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2023-02, Vol.30 (1), p.193-200
Main Authors: Jones, K.A., Paterson, C.A., Ray, S., Motherwell, D.W., Hamilton, D.J., Small, A.D., Martin, W., Goodfield, N.E.R.
Format: Article
Language:English
Subjects:
approximate entropy
beta-blockers
Cardiac dyssynchrony
Cardiology
Gated Blood-Pool Imaging
Heart Failure
Humans
Imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Original
Original Article
Radiology
Radionuclide Ventriculography
Retrospective Studies
RNVG phase
sample entropy
Stroke Volume
Ventricular Dysfunction, Left
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Summary:Radionuclide ventriculography (RNVG) can be used to quantify mechanical dyssynchrony and may be a valuable adjunct in the assessment of heart failure with reduced ejection fraction (HFrEF). The study aims to investigate the effect of beta-blockers on mechanical dyssynchrony using novel RNVG phase parameters. A retrospective study was carried out in a group of 98 patients with HFrEF. LVEF and dyssynchrony were assessed pre and post beta-blockade. Dyssynchrony was assessed using synchrony, entropy, phase standard deviation, approximate entropy, and sample entropy from planar RNVG phase images. Subgroups split by ischemic etiology were also investigated. An improvement in dyssynchrony and LVEF was measured six months post beta-blockade for both ischemic and non-ischemic groups. A significant improvement in dyssynchrony and LVEF was measured post beta-blockade using novel measures of dyssynchrony.
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-022-03142-x