Dupuytren’s disease is a work-related disorder: results of a population-based cohort study

ObjectivesDupuytren’s disease (DD) is a fibroproliferative disorder of the hands, characterised by the development of fibrous nodules and cords that may cause disabling contractures of the fingers. The role of manual work exposure in the aetiology of DD is controversial. We investigated whether curr...

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Bibliographic Details
Published in:Occupational and environmental medicine (London, England) England), 2023-03, Vol.80 (3), p.137-145
Main Authors: van den Berge, Bente A., Wiberg, Akira, Werker, Paul M. N., Broekstra, Dieuwke C., Furniss, Dominic
Format: Article
Language:English
Subjects:
Alcohol use
Biobanks
Body mass index
Classification
Cohort analysis
Cohort Studies
Connective tissue diseases
Drug dosages
Dupuytren Contracture - epidemiology
Dupuytren Contracture - etiology
Etiology
Exposure
Fingers
Hand
Hands
Humans
Hypertension
Likert scale
Nodules
Occupational exposure
Occupational Health
Occupations
Population studies
Population-based studies
Preventive medicine
Questionnaires
Regression models
Respiratory diseases
Risk Factors
Self report
Surgeons
Surgery
Work measurement
Workplace
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Summary:ObjectivesDupuytren’s disease (DD) is a fibroproliferative disorder of the hands, characterised by the development of fibrous nodules and cords that may cause disabling contractures of the fingers. The role of manual work exposure in the aetiology of DD is controversial. We investigated whether current occupational exposure to manual work is associated with DD, and if there is a dose–response relationship.MethodsIn this population-based cohort analysis, we used data from the UK Biobank cohort. Our primary outcome was the presence of DD. The exposure of interest was manual work, measured for each participant in two different ways to allow two independent analyses to be undertaken: (1) the current manual work status of the occupation at the time of recruitment, and (2) a cumulative manual work exposure score, calculated based on the occupational history. We performed propensity score matching and applied a logistic regression model.ResultsWe included 196 265 participants for the current manual work analysis, and 96 563 participants for the dose–response analysis. Participants whose current occupation usually/always involved manual work were more often affected with DD than participants whose occupation sometimes/never involved manual work (OR 1.29, 95% CI 1.12 to 1.49, p
ISSN:1351-0711
1470-7926
DOI:10.1136/oemed-2022-108670