Association of Brain Volume and Retinal Thickness in the Early Stages of Alzheimer’s Disease

Background: The eye has been considered a ‘window to the brain,’ and several neurological diseases including neurodegenerative conditions like Alzheimer’s disease (AD) also show changes in the retina. Objective: To investigate retinal nerve fiber layer (RNFL) thickness and its association with brain...

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Bibliographic Details
Published in:Journal of Alzheimer's disease 2023-01, Vol.91 (2), p.743-752
Main Authors: Mathew, Sunu, WuDunn, Darrell, Mackay, Devin D., Vosmeier, Aaron, Tallman, Eileen F., Deardorff, Rachael, Harris, Alon, Farlow, Martin R., Brosch, Jared R., Gao, Sujuan, Apostolova, Liana G., Saykin, Andrew J., Risacher, Shannon L.
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - pathology
Alzheimer's disease
Amygdala
Brain
Brain - diagnostic imaging
Brain - pathology
Cognitive ability
Cognitive Dysfunction - pathology
Correlation
Demographics
Eye
Hippocampus
Humans
Magnetic resonance imaging
Nerve Fibers - pathology
Neurodegeneration
Neurodegenerative diseases
Neuroimaging
Neurological diseases
Occipital lobe
Older people
Retina
Retina - diagnostic imaging
Retina - pathology
Statistical analysis
Temporal lobe
Thickness
Tomography, Optical Coherence - methods
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Summary:Background: The eye has been considered a ‘window to the brain,’ and several neurological diseases including neurodegenerative conditions like Alzheimer’s disease (AD) also show changes in the retina. Objective: To investigate retinal nerve fiber layer (RNFL) thickness and its association with brain volume via magnetic resonance imaging (MRI) in older adults with subjective or objective cognitive decline. Methods: 75 participants underwent ophthalmological and neurological evaluation including optical coherence tomography and MRI (28 cognitively normal subjects, 26 with subjective cognitive decline, 17 patients diagnosed with mild cognitive impairment, and 4 with AD). Differences in demographics, thickness of RNFL, and brain volume were assessed using ANCOVA, while partial Pearson correlations, covaried for age and sex, were used to compare thickness of the peripapillary RNFL with brain volumes, with p 
ISSN:1387-2877
1875-8908
DOI:10.3233/JAD-210533