Kidney function, bone-mineral metabolism markers, and calcification of coronary arteries, aorta, and cardiac valves in older adults

The contribution of kidney dysfunction, especially at mild-to-moderate stages, and bone-mineral metabolism (BMM) markers to vascular calcification remains controversial or unclear. We comprehensively evaluated the association of kidney and BMM markers with coronary artery calcification (CAC) and ext...

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Bibliographic Details
Published in:Atherosclerosis 2023-03, Vol.368, p.35-43
Main Authors: Mok, Yejin, Wang, Frances, Ballew, Shoshana H., Menez, Steve, Butler, Kenneth R., Wagenknecht, Lynne, Sedaghat, Sanaz, Lutsey, Pamela L., Coresh, Josef, Blaha, Michael J., Matsushita, Kunihiro
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aorta - metabolism
Aortic Valve - metabolism
Biomarkers
Calcification
Coronary Artery Disease
Coronary Vessels
Cystatin C
Humans
Kidney
Minerals - metabolism
Older adults
Phosphorus
Risk Factors
Vascular Calcification
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Summary:The contribution of kidney dysfunction, especially at mild-to-moderate stages, and bone-mineral metabolism (BMM) markers to vascular calcification remains controversial or unclear. We comprehensively evaluated the association of kidney and BMM markers with coronary artery calcification (CAC) and extra-coronary calcification (ECC). In 1931 ARIC participants (age 73–95 years) without coronary heart disease at visit 7 (2018–19), we investigated the associations of estimated glomerular filtration rate (eGFR) (with creatinine, cystatin C, and both) and five serum BMM markers (calcium, fibroblast growth factor 23, magnesium, parathyroid hormone, and phosphorus) with high CAC and ECC (sex-race specific ≥75th vs.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2023.01.007