Berberis lyceum root bark extract attenuates anticancer drugs induced neurotoxicityand cardiotoxicity in rats

Traditionally, was extensively used for the treatment of several human diseases. This study was undertaken to determine in vivo effects of Berberis lyceum root bark against doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity in Sprague Dawley rats. A single dose of doxorubicin (20...

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Bibliographic Details
Published in:African health sciences 2022-09, Vol.22 (3), p.192-210
Main Authors: Qurat-Ul-Ain, Sidra, Rukhsana, Anwar, Tariq, Sahar Isma, Kanwal, Ashiq
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Antioxidants - pharmacology
Berberis - metabolism
Cardiotoxicity
Cisplatin - pharmacology
Creatine Kinase
Doxorubicin
Humans
Oxidative Stress
Plant Bark - metabolism
Rats
Rats, Sprague-Dawley
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Summary:Traditionally, was extensively used for the treatment of several human diseases. This study was undertaken to determine in vivo effects of Berberis lyceum root bark against doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity in Sprague Dawley rats. A single dose of doxorubicin (20 mg/ kg i. p) and cisplatin (4mg/kg i.p) was used to induce cardiotoxicity and neurotoxicity, respectively. Berberis lyceum methanolic extract was given orally (200 and 400 mg/ kg) to toxicity-induced rats. The cardiac biomarkers i.e. serum aspartate aminotransferase, alanine transaminase, lactate dehydrogenase, creatine kinase and creatine kinase MB were analyzed in blood collected from cardiotoxic rats. The tissue oxidative stress markers included protein, glutathione s-transferase specific activity, catalase activity, total glutathione, and malondialdehyde levels were measured in cardiac and brain homogenate of the respective groups. Berberis lyceum methanolic extract has the potential to reduce the doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity significantly (*p
ISSN:1680-6905
1729-0503
DOI:10.4314/ahs.v22i3.22