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Berberis lyceum root bark extract attenuates anticancer drugs induced neurotoxicityand cardiotoxicity in rats
Traditionally, was extensively used for the treatment of several human diseases. This study was undertaken to determine in vivo effects of Berberis lyceum root bark against doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity in Sprague Dawley rats. A single dose of doxorubicin (20...
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| Published in: | African health sciences 2022-09, Vol.22 (3), p.192-210 |
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| Language: | English |
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| container_end_page | 210 |
| container_issue | 3 |
| container_start_page | 192 |
| container_title | African health sciences |
| container_volume | 22 |
| creator | Qurat-Ul-Ain, Sidra Rukhsana, Anwar Tariq, Sahar Isma Kanwal, Ashiq |
| description | Traditionally,
was extensively used for the treatment of several human diseases.
This study was undertaken to determine in vivo effects of Berberis lyceum root bark against doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity in Sprague Dawley rats.
A single dose of doxorubicin (20 mg/ kg i. p) and cisplatin (4mg/kg i.p) was used to induce cardiotoxicity and neurotoxicity, respectively. Berberis lyceum methanolic extract was given orally (200 and 400 mg/ kg) to toxicity-induced rats. The cardiac biomarkers i.e. serum aspartate aminotransferase, alanine transaminase, lactate dehydrogenase, creatine kinase and creatine kinase MB were analyzed in blood collected from cardiotoxic rats. The tissue oxidative stress markers included protein, glutathione s-transferase specific activity, catalase activity, total glutathione, and malondialdehyde levels were measured in cardiac and brain homogenate of the respective groups.
Berberis lyceum methanolic extract has the potential to reduce the doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity significantly (*p |
| doi_str_mv | 10.4314/ahs.v22i3.22 |
| format | article |
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was extensively used for the treatment of several human diseases.
This study was undertaken to determine in vivo effects of Berberis lyceum root bark against doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity in Sprague Dawley rats.
A single dose of doxorubicin (20 mg/ kg i. p) and cisplatin (4mg/kg i.p) was used to induce cardiotoxicity and neurotoxicity, respectively. Berberis lyceum methanolic extract was given orally (200 and 400 mg/ kg) to toxicity-induced rats. The cardiac biomarkers i.e. serum aspartate aminotransferase, alanine transaminase, lactate dehydrogenase, creatine kinase and creatine kinase MB were analyzed in blood collected from cardiotoxic rats. The tissue oxidative stress markers included protein, glutathione s-transferase specific activity, catalase activity, total glutathione, and malondialdehyde levels were measured in cardiac and brain homogenate of the respective groups.
Berberis lyceum methanolic extract has the potential to reduce the doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity significantly (*p<0.05) by reducing the serum markers and oxidative stress parameters. Histopathological analysis exhibited a marked improvement in the morphology of cardiac and brain tissues.
It is concluded that methanolic extract of Berberis lyceum root bark has the potential to protect and reverse anticancer drugs induced cardiotoxicity and neurotoxicity.</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>DOI: 10.4314/ahs.v22i3.22</identifier><identifier>PMID: 36910359</identifier><language>eng</language><publisher>Uganda: Makerere Medical School</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antioxidants - pharmacology ; Berberis - metabolism ; Cardiotoxicity ; Cisplatin - pharmacology ; Creatine Kinase ; Doxorubicin ; Humans ; Oxidative Stress ; Plant Bark - metabolism ; Rats ; Rats, Sprague-Dawley</subject><ispartof>African health sciences, 2022-09, Vol.22 (3), p.192-210</ispartof><rights>2022 Qurat-ul-Ain S et al.</rights><rights>2022 Qurat-ul-Ain S et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993256/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993256/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36910359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qurat-Ul-Ain, Sidra</creatorcontrib><creatorcontrib>Rukhsana, Anwar</creatorcontrib><creatorcontrib>Tariq, Sahar Isma</creatorcontrib><creatorcontrib>Kanwal, Ashiq</creatorcontrib><title>Berberis lyceum root bark extract attenuates anticancer drugs induced neurotoxicityand cardiotoxicity in rats</title><title>African health sciences</title><addtitle>Afr Health Sci</addtitle><description>Traditionally,
was extensively used for the treatment of several human diseases.
This study was undertaken to determine in vivo effects of Berberis lyceum root bark against doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity in Sprague Dawley rats.
A single dose of doxorubicin (20 mg/ kg i. p) and cisplatin (4mg/kg i.p) was used to induce cardiotoxicity and neurotoxicity, respectively. Berberis lyceum methanolic extract was given orally (200 and 400 mg/ kg) to toxicity-induced rats. The cardiac biomarkers i.e. serum aspartate aminotransferase, alanine transaminase, lactate dehydrogenase, creatine kinase and creatine kinase MB were analyzed in blood collected from cardiotoxic rats. The tissue oxidative stress markers included protein, glutathione s-transferase specific activity, catalase activity, total glutathione, and malondialdehyde levels were measured in cardiac and brain homogenate of the respective groups.
Berberis lyceum methanolic extract has the potential to reduce the doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity significantly (*p<0.05) by reducing the serum markers and oxidative stress parameters. Histopathological analysis exhibited a marked improvement in the morphology of cardiac and brain tissues.
It is concluded that methanolic extract of Berberis lyceum root bark has the potential to protect and reverse anticancer drugs induced cardiotoxicity and neurotoxicity.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Berberis - metabolism</subject><subject>Cardiotoxicity</subject><subject>Cisplatin - pharmacology</subject><subject>Creatine Kinase</subject><subject>Doxorubicin</subject><subject>Humans</subject><subject>Oxidative Stress</subject><subject>Plant Bark - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1680-6905</issn><issn>1729-0503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVkU1v1DAQhi1ERT_gxhn5yIFsPXbsbC5ItIKCVKkXOFsTe9IaErvYTtX9901pWcHJI8-jd2b0MPYWxKZV0J7iTdncSRnURsoX7Ag62TdCC_Vyrc1WNKYX-pAdl_JTCGmgh1fsUJkehNL9EZvPKA-UQ-HTztEy85xS5QPmX5zua0ZXOdZKccFKhWOswWF0lLnPy3XhIfrFkeeRlpxqug8u1B1Gzx1mH_Y_K8cz1vKaHYw4FXrz_J6wH18-fz__2lxeXXw7_3TZOCVUbcwoJG59J0GOqGlUgzZAHQAIMoq0ly2YtiUFOAD0vZLgSbWdEnqUBkmdsI9PubfLMJN3FNdTJnubw4x5ZxMG-38nhht7ne5s_ximzRrw_jkgp98LlWrnUBxNE0ZKS7Gy2xoNSki9oh-eUJdTKZnG_RgQ9tGQXQ3ZP4aslCv-7t_V9vBfJeoBkLyQnA</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Qurat-Ul-Ain, Sidra</creator><creator>Rukhsana, Anwar</creator><creator>Tariq, Sahar Isma</creator><creator>Kanwal, Ashiq</creator><general>Makerere Medical School</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220901</creationdate><title>Berberis lyceum root bark extract attenuates anticancer drugs induced neurotoxicityand cardiotoxicity in rats</title><author>Qurat-Ul-Ain, Sidra ; Rukhsana, Anwar ; Tariq, Sahar Isma ; Kanwal, Ashiq</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-6f02a8d7212fa5ef3b561e71110e63e5d241644e31ab1199321de347305f26ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Berberis - metabolism</topic><topic>Cardiotoxicity</topic><topic>Cisplatin - pharmacology</topic><topic>Creatine Kinase</topic><topic>Doxorubicin</topic><topic>Humans</topic><topic>Oxidative Stress</topic><topic>Plant Bark - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qurat-Ul-Ain, Sidra</creatorcontrib><creatorcontrib>Rukhsana, Anwar</creatorcontrib><creatorcontrib>Tariq, Sahar Isma</creatorcontrib><creatorcontrib>Kanwal, Ashiq</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qurat-Ul-Ain, Sidra</au><au>Rukhsana, Anwar</au><au>Tariq, Sahar Isma</au><au>Kanwal, Ashiq</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Berberis lyceum root bark extract attenuates anticancer drugs induced neurotoxicityand cardiotoxicity in rats</atitle><jtitle>African health sciences</jtitle><addtitle>Afr Health Sci</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>22</volume><issue>3</issue><spage>192</spage><epage>210</epage><pages>192-210</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><abstract>Traditionally,
was extensively used for the treatment of several human diseases.
This study was undertaken to determine in vivo effects of Berberis lyceum root bark against doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity in Sprague Dawley rats.
A single dose of doxorubicin (20 mg/ kg i. p) and cisplatin (4mg/kg i.p) was used to induce cardiotoxicity and neurotoxicity, respectively. Berberis lyceum methanolic extract was given orally (200 and 400 mg/ kg) to toxicity-induced rats. The cardiac biomarkers i.e. serum aspartate aminotransferase, alanine transaminase, lactate dehydrogenase, creatine kinase and creatine kinase MB were analyzed in blood collected from cardiotoxic rats. The tissue oxidative stress markers included protein, glutathione s-transferase specific activity, catalase activity, total glutathione, and malondialdehyde levels were measured in cardiac and brain homogenate of the respective groups.
Berberis lyceum methanolic extract has the potential to reduce the doxorubicin-induced cardiotoxicity and cisplatin-induced neurotoxicity significantly (*p<0.05) by reducing the serum markers and oxidative stress parameters. Histopathological analysis exhibited a marked improvement in the morphology of cardiac and brain tissues.
It is concluded that methanolic extract of Berberis lyceum root bark has the potential to protect and reverse anticancer drugs induced cardiotoxicity and neurotoxicity.</abstract><cop>Uganda</cop><pub>Makerere Medical School</pub><pmid>36910359</pmid><doi>10.4314/ahs.v22i3.22</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1680-6905 |
| ispartof | African health sciences, 2022-09, Vol.22 (3), p.192-210 |
| issn | 1680-6905 1729-0503 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9993256 |
| source | PubMed Central (PMC) |
| subjects | Animals Antineoplastic Agents - pharmacology Antioxidants - pharmacology Berberis - metabolism Cardiotoxicity Cisplatin - pharmacology Creatine Kinase Doxorubicin Humans Oxidative Stress Plant Bark - metabolism Rats Rats, Sprague-Dawley |
| title | Berberis lyceum root bark extract attenuates anticancer drugs induced neurotoxicityand cardiotoxicity in rats |
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