Crystal structures of two 1,2,3,4-tetra-hydro-naphthalenes obtained during efforts towards the total synthesis of elisabethin A

• Published in: Acta crystallographica. Section E, Crystallographic communications Crystallographic communications, 2023-02, Vol.79 (Pt 3), p.177-181
• Main Authors: Kaiser, Maximilian, Weil, Matthias, Gärtner, Peter, Enev, Valentin
• Format: Article
• Language: English
• Subjects: Research Communications
• ISSN: 2056-9890; 2056-9890
• DOI: 10.1107/S2056989023001226

The two substituted 1,2,3,4-tetra-hydro-naphthalenes, methyl ( )-3-{(1 ,4 )-6-meth-oxy-4,7-dimethyl-5,8-bis-[(triiso-propyl-sil-yl)-oxy]-1,2,3,4-tetra-hydro-naph-th-al-en-1-yl}butano-ate, C H O Si , ( ), and methyl ( )-3-{(1 ,4 )-8-hy-droxy-6-meth-oxy-4,7-dimethyl-5-[(triiso-propyl-sil-yl)-oxy]-1,2,3,4-tetra-hydro-naphthalen-1-yl}acrylate, C H O Si, ( ), crystallize in the Sohncke space groups 2 2 2 and 2 , respectively, with the absolute structure determined on the basis of anomalous dispersion effects. The configurations of the stereo centres in the 1,2,3,4-tetra-hydro-naphthalene moiety of ( ) and ( ) are the same, and the conformation of the non-aromatic part of the ring system is nearly identical. In the crystal of ( ), weak non-classical C-H⋯O inter-actions consolidate the packing, whereas in ( ), inter-molecular O-H⋯O hydrogen-bonding inter-actions of medium-to-weak strength direct the mol-ecules into -shaped strands extending parallel to [010].