Ameliorative role of nanocurcumin against the toxicological effects of novel forms of Cuo as nanopesticides: a comparative study

Copper oxide nanoparticles (CuONPs) have a wide range of uses in agricultural applications. Nanocurcumin (NCur) acts as an antioxidant treatment. The goal of the study is to reduce the toxicity resulting from the use of CuONPs as nanopesticides on living organisms by inducing changes in the morpholo...

Full description

Saved in:
Bibliographic Details
Published in:Environmental science and pollution research international 2023-02, Vol.30 (10), p.26270-26291
Main Authors: Abdel-Azeem, Abeer M, Abdel-Rehiem, Eman S, Farghali, Ahmed A, Khidr, Fatma K, Abdul-Hamid, Manal
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
bcl-2-Associated X Protein
Copper - adverse effects
Copper - chemistry
Copper - toxicity
Curcumin - pharmacology
Curcumin - therapeutic use
Glutathione - metabolism
Nanoparticles - adverse effects
Nanoparticles - chemistry
Nanoparticles - toxicity
Oxidative Stress
Pesticides - adverse effects
Pesticides - chemistry
Pesticides - toxicity
Rats
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Copper oxide nanoparticles (CuONPs) have a wide range of uses in agricultural applications. Nanocurcumin (NCur) acts as an antioxidant treatment. The goal of the study is to reduce the toxicity resulting from the use of CuONPs as nanopesticides on living organisms by inducing changes in the morphological shape of CuONPs or treating it with NCur. So, we induced a comparative study between three shapes of CuONPs: CuO nanosphere (CuONSp), CuO nanosheet (CuONS), and CuO nanoflower (CuONF). We characterize each nano-form by using X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (HRTEM), and Zetasizer HT device; 36 rats were divided into six groups (n = 6): 1st group was the control group; 2nd group received 50 mg/kg/day of NCur orally for 30 days; 3rd, 4th, and 5th groups received orally 50 mg/kg/day of CuONSp, CuONS, and CuONF, respectively, for 30 days; 6th group received 50 mg/kg/day CuONSp plus 50 mg/kg/day of NCur orally for 30 days. An elevation occurred in malondialdehyde (MDA), liver and kidney functions, tumor necrosis factor-alpha (TNF-α), and B-cell lymphoma 2 (Bcl2) by CuONSp > CuONS > CuONF, respectively. An inhibition occurred in glutathione (GSH), superoxidase (SOD) catalase (CAT), apoptotic Bax gene (Bax), histopathological, and ultrastructural alterations by CuONSp 
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-022-23886-w